Disease state changes and safety of long-term donepezil hydrochloride administration in patients with Alzheimer's disease: interim results from the long-term, large-scale J-GOLD study in Japan
| Autor: | Heii Arai, Takao Takase, Yukinori Sakata, Kenta Sumitomo, Tetsumi Toyoda, Kasumi Daidoji |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Activities of daily living Exacerbation Population 03 medical and health sciences 0302 clinical medicine Cognition Japan Piperidines Donepezil Hydrochloride Alzheimer Disease Activities of Daily Living Medicine Dementia Humans Donepezil Prospective Studies education Prospective cohort study Aged Aged 80 and over education.field_of_study Mini–Mental State Examination 030214 geriatrics medicine.diagnostic_test business.industry Middle Aged medicine.disease Long-Term Care Psychiatry and Mental health Treatment Outcome Indans Physical therapy Female Cholinesterase Inhibitors Geriatrics and Gerontology business Mental Status Schedule Gerontology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. 16(2) |
| ISSN: | 1479-8301 |
| Popis: | Background There have been very few long-term studies involving a large study population; existing studies usually have no more than a few hundred patients with Alzheimer's disease. For these reasons, there are no detailed investigations regarding changes in activities of daily living evaluated by the Functional Assessment Staging Test (FAST). Methods A long-term, large-scale observational study of donepezil hydrochloride (Aricept®; Eisai Co., Ltd, Tokyo, Japan) is currently in progress. Its objective is to investigate disease state changes associated with the long-term administration of this drug and its safety in patients with Alzheimer's disease. In this report, data collected over a maximum of 24 months were compiled. Efficacy was assessed using FAST and a cognitive function test (Mini-Mental State Examination or the Hasegawa's Dementia Scale-Revised). Results The percentages of patients whose FAST stage improved or remained the same compared to at the start of donepezil hydrochloride administration (baseline) were 91.1% at 6 months, 83.0% at 12 months, 79.5% at 18 months, and 74.8% at 24 months. Multivariate logistic regression analysis was conducted to investigate factors that affect the improvement and maintenance or exacerbation of FAST at 24 months. ‘Independence level in the daily life of elderly with dementia’ and ‘duration of illness’ were identified as variables that affected the improvement and maintenance or exacerbation of FAST. Cognitive function improved significantly at 12 weeks and at 6 months compared to baseline, maintained baseline levels at 12 months and at 18 months, and decreased significantly at 24 months compared to baseline. Conclusions This is the largest prospective study involving Alzheimer's disease patients in Japan, and we believe it is an important study that shows the reality of daily clinical practice. |
| Databáze: | OpenAIRE |
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