Assessing the effects of long-term osteoporosis treatment by using conventional spine radiographs: results from a pilot study in a sub-cohort of a large randomized controlled trial

Autor: Stefan Nehrer, Astrid Fahrleitner-Pammer, Andreas Kurth, R. Ljuhar, Hans Peter Dimai, D. Ljuhar, B. Norman
Rok vydání: 2018
Předmět:
musculoskeletal diseases
medicine.medical_specialty
Osteoporosis
Urology
Pilot Projects
030218 nuclear medicine & medical imaging
law.invention
03 medical and health sciences
Absorptiometry
Photon
0302 clinical medicine
Lumbar
Randomized controlled trial
Bone Density
law
medicine
Humans
Scientific Article
Radiology
Nuclear Medicine and imaging
Osteoporosis
Postmenopausal
Aged
Aged
80 and over
030203 arthritis & rheumatology
Bone mineral
Lumbar Vertebrae
Bone Density Conservation Agents
business.industry
Long-term treatment
Reproducibility of Results
Repeated measures design
Middle Aged
medicine.disease
Dual X-ray absorptiometry (DXA)
Bone structure value (BSV)
Treatment Outcome
Denosumab
Orthopedic surgery
Cohort
Radiographic Image Interpretation
Computer-Assisted
Female
business
Software
Conventional radiograph
medicine.drug
Zdroj: Skeletal Radiology
ISSN: 1432-2161
0364-2348
DOI: 10.1007/s00256-018-3118-y
Popis: Objective To evaluate the clinical applicability of a software tool developed to extract bone textural information from conventional lumbar spine radiographs, and to test it in a subset of postmenopausal women treated for osteoporosis with the fully human monoclonal antibody denosumab. Methods The software was developed based on the principles of a fractal model using pixel grey-level variations together with a specific machine-learning algorithm. The obtained dimensionless parameter, termed bone structure value (BSV), was then tested and compared to bone mineral density (BMD) in a sub-cohort of postmenopausal women with osteoporosis who were treated with the monoclonal antibody denosumab, within the framework of a large randomized controlled trial and its open-label extension phase. Results After 3 years and after 8 years of treatment with denosumab, mean lumbar spine BMD as well as mean lumbar BSV were significantly higher compared to study entry (one-way repeated measures ANOVA for DXA: F = 108.2, p
Databáze: OpenAIRE
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