| Autor: |
Daichi Sone, Marian Galovic, Jim Myers, Georg Leonhardt, Ilan Rabiner, John S. Duncan, Matthias J. Koepp, Jacqueline Foong |
| Přispěvatelé: |
University of Zurich, Koepp, Matthias J, Foong, Jacqueline |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
EpilepsiaREFERENCES. |
| ISSN: |
1528-1167 |
| Popis: |
Affective disorders are frequent comorbidities of temporal lobe epilepsy (TLE). The endogenous opioid system has been implicated in both epilepsy and affective disorders, and may play a significant role in their bidirectional relationship. In this cross-sectional study, we investigated the association between μ-opioid receptor binding and affective disorders in patients with TLE.Nine patients with TLE and depression/anxiety underwentWe observed widely reduced CFN binding potential (BP) in bilateral frontal lobes and striata in patients with TLE compared to healthy controls. In the TLE group, more severe anxiety and negative affect were associated with decreased CFN BP in the posterior cingulate gyrus.In patients with TLE, interictally reduced binding in the opioid system was associated with higher levels of anxiety and negative affect. We speculate that seizure-related agonist-driven desensitization and downregulation of opioid receptors could be a potential underlying pathomechanism. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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