Interrelations of dietary and hormonal effects in aging
| Autor: | Paul E. Segall |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Aging
medicine.medical_specialty Central nervous system Hypothalamus Secretomotor Stimulation Biology Autonomic Nervous System Inhibitory postsynaptic potential Models Biological Biological Clocks Pituitary Gland Anterior Pituitary Hormones Anterior Internal medicine medicine Animals Involution (medicine) Muscles Tryptophan Muscle Smooth Diet Rats Autonomic nervous system Endocrinology medicine.anatomical_structure Genes Spinal Cord Homeostasis Developmental Biology Hormone |
| Zdroj: | Mechanisms of Ageing and Development. 9:515-525 |
| ISSN: | 0047-6374 |
| DOI: | 10.1016/0047-6374(79)90091-5 |
| Popis: | A model system is proposed which suggests that aging involves a genetically programmed process encoded within specific regions of the central nervous system and is characterized by a gradual ascendency of inhibitory over excitatory influences. The resulting neural suppression reduces tonic stimulation to the hypothalamus-pituitary-endocrine axis, the autonomic nervous system and the spinal cord, and promotes the secretion of inactive pituitary hormone, the involution of the somatic musculature (smooth, cardiac and striated) and the compromise of secretomotor function. Experimental observations from nutritional restriction studies which include the prolongation of the life-span and delays in reproductive and homeostatic aging, degenerative coat changes and the appearance of neoplasia, are considered from the perspective of this hypothesis. |
| Databáze: | OpenAIRE |
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