A case of eccrine porocarcinoma characterized by a progressive increase in the level of Ki-67 index: case report and review of literature
| Autor: | Yongfu Lu, Yue-Hui Ma, Xinfa Pan, Jie Shen, Renya Zhan, De-Sheng Pan |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms Eccrine carcinoma medicine.medical_treatment lcsh:Surgery Hidradenocarcinoma Case Report Metastasis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Invasion Biopsy medicine Humans Dura Scalp medicine.diagnostic_test business.industry lcsh:RD1-811 General Medicine Eccrine porocarcinoma medicine.disease Immunohistochemistry Surgery Radiation therapy Transplantation Sweat Gland Neoplasms Sweat gland carcinoma medicine.anatomical_structure Ki-67 Antigen 030220 oncology & carcinogenesis Lymph Node Excision Ki-67 Lymphadenectomy business |
| Zdroj: | BMC Surgery BMC Surgery, Vol 19, Iss 1, Pp 1-8 (2019) |
| ISSN: | 1471-2482 |
| Popis: | BackgroundEccrine porocarcinoma is an extremely rare skin adnexal malignant neoplasia with highly invasive and metastatic potential. We report an additional case of eccrine porocarcinoma with intracranial metastases. This case is characterized by a complete record of the progress of eccrine porocarcinoma, its immunohistochemistry after three operations showed a progressive increase in the level of Ki-67 index.Case presentationWe herein report a case of a 37-year-old-male with eccrine carcinoma occurring on the left posterior occipital scalp which invaded the skull and dura, presenting with progressive headache. This patient has performed three surgeries in total. During the last hospitalization, he underwent an extended surgical resection, lymphadenectomy, myocutaneous flap transplantation and vascular anastomosis in our institution. After surgery, he was treating with radiotherapy at 200 Gray in 12 fractions. But one year after the operation, he developed chest tightness, imaging examination and biopsy puncture revealed pulmonary metastasis.ConclusionIntracranial metastasis of eccrine porocarcinoma is a late event with poor prognosis. This case emphases on that progressively increased level of Ki-67 index may predict more chance to occur the intracranial metastasis of scalp eccrine porocarcinoma, long-term follow-up and appropriately dense follow-up interval is necessary. |
| Databáze: | OpenAIRE |
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