Biomarkers in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia
| Autor: | Anna Sowińska, Dawid Szpecht, Barbara Michniewicz, Janusz Gadzinowski, Rafał Sibiak, Marta Szymankiewicz |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Aspartate transaminase Kidney failure Hepatic enzymes Gastroenterology chemistry.chemical_compound Troponin T Hypothermia Induced Pregnancy Internal medicine Medicine Humans Sarnat staging Prothrombin time Creatinine biology medicine.diagnostic_test business.industry Infant Newborn General Medicine Prognosis Perinatal asphyxia chemistry Alanine transaminase Pediatrics Perinatology and Child Health Hypoxia-Ischemia Brain biology.protein Base excess Original Article Female Partial Thromboplastin Time Neurology (clinical) business Biomarkers Partial thromboplastin time |
| Zdroj: | Child's Nervous System |
| ISSN: | 1433-0350 0256-7040 |
| Popis: | Purpose The aim of the presented study was to evaluate the differences between selected biochemical markers in infants with moderate or severe hypoxic-ischemic encephalopathy (HIE) and their impact on patient prognosis. Methods A total of 57 cooled newborns were divided into groups according to Sarnat staging of HIE (A, moderate vs. B, severe). The differences between groups were evaluated depending on the mode of delivery, pregnancy and labor complications, gestational age at birth, birth weight, and Apgar score at 1.3 and 5 min. The differences in biochemical biomarkers of HIE (pH, base excess, serum lactate) as well as biomarkers of hepatic injury (aspartate transaminase, (AST), alanine transaminase (ALT), prothrombin time (PT), and activated partial thromboplastin time (APTT)), kidney failure (creatinine, urea), myocardial injury (troponin T (TnT)), levels of fibrinogen, and platelet counts were also examined. Univariate Kaplan-Meier method was used for survival analyses. Results The biomarker levels in severe HIE newborns compared with moderate were as follows: pH (7.10 vs. 6.99), serum lactate (22.50 vs. 17.00 mg/dL), AST (109.50 vs. 270.55 IU/L), ALT (27.30 vs. 108.05 IU/L), PT (17.00 vs. 44.20 s), APTT (47.75 vs. 47.90 s), TnT (0.22 vs. 0.85 ng/mL), creatinine (0.68 vs. 1.15 mg/dL), urea (44.55 vs. 73.30 mg/dL), and fibrinogen (1.65 vs. 1.90 mg/dL). Survival analyses showed significantly reduced survival for severe HIE infants (75%) vs. moderate HIE (100%). Conclusion In conclusion, the severity of HIE can be evaluated based on selected markers; however, their levels do not correspond with future prognosis of newborns. |
| Databáze: | OpenAIRE |
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