A Placebo-Controlled Pilot Study of the Ampakine CX516 Added to Clozapine in Schizophrenia

Autor: Lawrence Herz, Andrew C. Leon, Ileana Berman, Leslie Leahy, Gary Lynch, Steven A. Johnson, Donald C. Goff, Thomas Posever
Rok vydání: 2001
Předmět:
Zdroj: Journal of Clinical Psychopharmacology. 21:484-487
ISSN: 0271-0749
DOI: 10.1097/00004714-200110000-00005
Popis: CX516, a positive modulator of the glutamatergic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor, improves performance in tasks requiring learning and memory in animals. CX516 was added to clozapine in 4-week, placebo-controlled, dose-finding (N = 6) and fixed-dose (N = 13) trials. CX516 was tolerated well and was associated with moderate to large, between-group effect sizes compared with placebo, representing improvement in measures of attention and memory. These preliminary results suggest that CX516 and other "ampakines" hold promise for the treatment of schizophrenia.
Databáze: OpenAIRE