Imaging of glutamate in acute traumatic brain injury using chemical exchange saturation transfer
Autor: | Yanzi Chen, Zerui Zhuang, Yuanyu Shen, Guisen Lin, Renhua Wu, Yifei Mao, Xiaolei Zhang |
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Rok vydání: | 2019 |
Předmět: |
medicine.diagnostic_test
Traumatic brain injury business.industry Chemical exchange Glutamate receptor Montreal Cognitive Assessment Magnetic resonance imaging Cognition medicine.disease 030218 nuclear medicine & medical imaging White matter 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Saturation transfer Anesthesia medicine Original Article Radiology Nuclear Medicine and imaging business 030217 neurology & neurosurgery |
Zdroj: | Quantitative Imaging in Medicine and Surgery. 9:1652-1663 |
ISSN: | 2223-4306 2223-4292 |
Popis: | BACKGROUND: Chemical exchange saturation transfer (CEST) is an important contrast mechanism in the field of magnetic resonance imaging. Herein, we used CEST for glutamate (GluCEST) imaging to evaluate the Glu alterations in acute mild to moderate traumatic brain injury (TBI) and correlated such alterations with the cognitive outcome at 1-month postinjury. METHODS: Thirty-two patients with well-documented mild-to-moderate TBI and 15 healthy controls (HC group) underwent 3.0-Tesla magnetic resonance imaging (MRI) with GluCEST, and magnetic resonance spectroscopy (MRS) scans. The Montreal Cognitive Assessment (MoCA) examination was administered to all study subjects at 1-month postinjury for cognitive outcome acquisition and divided TBI patients into patients with good cognitive outcome (GCO group) and with poor cognitive outcome (PCO group). RESULTS: The GluCEST% values for the occipital gray matter (OGM) and bilateral parietooccipital white matter (PWM) were higher in the PCO group compared with the HC and GCO groups (P0.05). In comparison with HCs, TBI patients had a significantly increased GluCEST% value for the OGM and bilateral PWM (P |
Databáze: | OpenAIRE |
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