Traveling waves in the prefrontal cortex during working memory
| Autor: | Mikael Lundqvist, Earl K. Miller, Sayak Bhattacharya, Scott L. Brincat |
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| Rok vydání: | 2021 |
| Předmět: |
Male
QH301-705.5 Acoustics Prefrontal Cortex Cellular and Molecular Neuroscience Beta band Planar Orientation (geometry) Cortex (anatomy) Task Performance and Analysis Genetics medicine Traveling wave Animals Biology (General) Prefrontal cortex Molecular Biology Ecology Evolution Behavior and Systematics Physics Quantitative Biology::Neurons and Cognition Ecology Working memory Spatial structure Computational Biology Brain Waves Macaca mulatta medicine.anatomical_structure Memory Short-Term Computational Theory and Mathematics Modeling and Simulation |
| Zdroj: | PLoS Computational Biology, Vol 18, Iss 1, p e1009827 (2022) |
| ISSN: | 1553-7358 |
| Popis: | Neural oscillations are evident across cortex but their spatial structure is not well-explored. Are oscillations stationary or do they form “traveling waves”, i.e., spatially organized patterns whose peaks and troughs move sequentially across cortex? Here, we show that oscillations in the prefrontal cortex (PFC) organized as traveling waves in the theta (4-8Hz), alpha (8-12Hz) and beta (12-30Hz) bands. Some traveling waves were planar but most rotated. The waves were modulated during performance of a working memory task. During baseline conditions, waves flowed bidirectionally along a specific axis of orientation. Waves in different frequency bands could travel in different directions. During task performance, there was an increase in waves in one direction over the other, especially in the beta band.Author SummaryWe found that oscillations in the prefrontal cortex form “traveling waves”. Traveling waves are spatially extended patterns in which aligned peaks of activity move sequentially across the cortical surface. Some traveling waves were planar but most rotated. The prefrontal cortex is important for working memory. The traveling waves changed when monkeys performed a working memory task. There was an increase in waves in one direction over the other, especially in the beta band. Traveling waves can serve specific functions. For example, they help maintain network status and help control timing relationships between spikes. Given their functional advantages, a greater understanding of traveling waves should lead to a greater understanding of cortical function. |
| Databáze: | OpenAIRE |
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