Histologic, Histomorphometric, and Clinical Analysis of the Effects of Growth Factors in a Fibrin Network Used in Maxillary Sinus Augmentation
| Autor: | Bahattin Gültekin, Vakur Olgaç, Eitan Mijiritsky, Serdar Yalçin, Ihsan Caglar Cinar, Alper Saglanmak |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
endocrine system
medicine.medical_specialty volume change Maxillary sinus maxillary sinus lifting Health Toxicology and Mutagenesis Sinus Floor Augmentation lcsh:Medicine Biocompatible Materials histomorphometry Article Fibrin 03 medical and health sciences 0302 clinical medicine Biopsy Humans Medicine Platelet Sinus (anatomy) Clinical pathology medicine.diagnostic_test biology business.industry lcsh:R fungi Public Health Environmental and Occupational Health 030206 dentistry Maxillary Sinus mineralized plasmatic matrix Implant placement medicine.anatomical_structure Trephine 030220 oncology & carcinogenesis biology.protein business Nuclear medicine beta-tricalcium phosphate |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 17 Issue 6 International Journal of Environmental Research and Public Health, Vol 17, Iss 6, p 1918 (2020) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph17061918 |
| Popis: | This randomized controlled clinical trial evaluated the effect of mineralized plasmatic matrix (MPM), comprised of synthetic graft and platelet concentrates, on new bone formation and volume stability over time in maxillary sinus lifting (MSL). Unilateral MSL was performed in 20 patients with either beta-tricalcium phosphate (&beta TCP) or MPM grafts (10 sinuses each). Six months postsurgery, specimens were obtained with a trephine bur prior to implant placement in 39 cases. Volumetric changes in sinus augmentation were analyzed between 1 week (T-I) and 6 months (T-II) postsurgery. Histomorphometric and histological analyses of biopsy samples revealed mean new bone percentages of 35.40% ± 9.09% and 26.92% ± 7.26% and residual graft particle areas of 23.13% ± 6.16% and 32.25% ± 8.48% in the MPM and &beta TCP groups, respectively (p < 0.05). The mean soft-tissue areas in the MPM and &beta TCP groups were 41.48% ± 8.41% and 40.83% ± 8.86%, respectively (p > 0.05). Graft reductions between baseline and 6-months postprocedure in the &beta TCP and MPM groups were 17.12% ± 13.55% and 14.41% ± 12.87%, respectively, with significant graft volume reduction observed in both groups (p < 0.05) while there is no significant difference between MPM and &beta TCP groups (p > 0.05). Thus, MPM, representing growth factors in a fibrin network, increases new bone formation and has acceptable volume stability in MSL procedures. |
| Databáze: | OpenAIRE |
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