In Vitro Antienterococcal Activity Explains Associations between Exposures to Antimicrobial Agents and Risk of Colonization by Multiresistant Enterococci
| Autor: | Rebecca Hutton-Thomas, Louis B. Rice, Marion S. Helfand, Viera LakticĎvaá |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Enterococcus faecium
Colony Count Microbial Penicillanic Acid Drug resistance Biology Microbiology Feces Mice Drug Resistance Multiple Bacterial Ampicillin polycyclic compounds medicine Animals Immunology and Allergy Colonization Gram-Positive Bacterial Infections Piperacillin Dose-Response Relationship Drug Ceftriaxone biochemical phenomena metabolism and nutrition biology.organism_classification Antimicrobial digestive system diseases Anti-Bacterial Agents Gastrointestinal Tract Disease Models Animal Piperacillin Tazobactam Drug Combination Infectious Diseases Enterococcus Carrier State Female medicine.drug |
| Zdroj: | The Journal of Infectious Diseases. 190:2162-2166 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/425580 |
| Popis: | We compared ceftriaxone and piperacillin-tazobactam at doses ranging from 0.1 to 2 times the human equivalent daily dose (HEDD), to determine their impact on gastrointestinal colonization by ampicillin- and vancomycin-resistant Enterococcus faecium C68 in a mouse model. Ceftriaxone failed to promote colonization at doses up to 0.25 times the HEDD, whereas piperacillin-tazobactam promoted colonization at doses up to 0.5 times the HEDD. Ceftriaxone promoted colonization at doses at least 0.5 times the HEDD, whereas piperacillin-tazobactam inhibited colonization at doses at least 0.75 times the HEDD. Both piperacillin-tazobactam and ceftriaxone inhibited colonization by an enterococcal strain devoid of low-affinity penicillin-binding protein-5 (significantly increasing its susceptibility to these agents), at doses that promoted colonization by E. faecium C68. These results support a model in which the impact that different beta -lactam agents have on colonization by VRE is related to the level of the beta -lactam agent's intrinsic antienterococcal activity against the colonizing strain. |
| Databáze: | OpenAIRE |
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