Escitalopram Versus SNRI Antidepressants in the Acute Treatment of Major Depressive Disorder: Integrative Analysis of Four Double-Blind, Randomized Clinical Trials

Autor: George I. Papakostas, Yongcai Mao, Sara Larsson, Dayong Li, Henning F Andersen, Susan G. Kornstein
Rok vydání: 2009
Předmět:
Adult
Male
medicine.medical_specialty
Time Factors
Adolescent
Venlafaxine
Thiophenes
Citalopram
Duloxetine Hydrochloride
Severity of Illness Index
Drug Administration Schedule
law.invention
Young Adult
symbols.namesake
chemistry.chemical_compound
Double-Blind Method
Randomized controlled trial
Norepinephrine reuptake inhibitor
law
Internal medicine
Outcome Assessment
Health Care
medicine
Humans
Escitalopram
Duloxetine
Psychiatry
Fisher's exact test
Aged
Randomized Controlled Trials as Topic
Aged
80 and over
Psychiatric Status Rating Scales
Depressive Disorder
Major
Venlafaxine Hydrochloride
Middle Aged
Cyclohexanols
medicine.disease
Psychiatry and Mental health
chemistry
symbols
Major depressive disorder
Female
Neurology (clinical)
Psychology
Selective Serotonin Reuptake Inhibitors
medicine.drug
Zdroj: CNS Spectrums. 14:326-333
ISSN: 2165-6509
1092-8529
Popis: Introduction: Recent data suggest that escitalopram may be more effective in severe depression than other selective serotonin reuptake inhibitors.Methods: Individual patient data from four randomized, double-blind comparative trials of escitalopram versus a serotonin/norepinephrine reuptake inhibitor (SNRI) (two trials with duloxetine and two with venlafaxine extended release) in outpatients (18–85 years of age) with moderate-to-severe major depressive disorder were pooled. The primary efficacy parameter in all four trials was mean change in the Montgomery-Asberg Depression Rating Scale (MADRS) score.Results: Significantly fewer escitalopram (82/524) than SNRI (114/527) patients prematurely withdrew from treatment due to all causes (15.6% vs. 21.6%, Fisher Exact: P=.014) and adverse events (5.3% vs. 12.0%, Fisher Exact: P P P Conclusion: This pooled analysis indicates that escitalopram is at least as effective as the SNRIs (venlafaxine XR and duloxetine), even in severe depression, and escitalopram treatment was better tolerated.
Databáze: OpenAIRE
Externí odkaz: