Diabetes and cardiovascular events in women with polycystic ovary syndrome: a 20-year retrospective cohort study
| Autor: | Hamidreza Mani, John Bankart, Trevor A. Howlett, Hannah Blackledge, Miles J Levy, Laura J. Gray, Kamlesh Khunti, Melanie J. Davies, Danielle H. Morris |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Population Myocardial Infarction Angina Pectoris Cohort Studies Angina Endocrinology Internal medicine Prevalence medicine Humans Myocardial infarction education Retrospective Studies Heart Failure education.field_of_study business.industry Incidence Incidence (epidemiology) Retrospective cohort study Odds ratio Middle Aged medicine.disease Polycystic ovary United Kingdom Stroke Diabetes Mellitus Type 2 Cardiovascular Diseases Cohort Female business Polycystic Ovary Syndrome |
| Zdroj: | Clinical Endocrinology. 78:926-934 |
| ISSN: | 0300-0664 |
| DOI: | 10.1111/cen.12068 |
| Popis: | SummaryObjective Women with polycystic ovary syndrome (PCOS) are potentially at increased risk of cardiovascular (CV) diseases due to well-established risk factors, including insulin resistance, obesity and type 2 diabetes mellitus (T2DM). However, data showing excess CV events in this population are still lacking. We investigated the incidence and prevalence of CV events in a cohort of women with PCOS. Design Retrospective cohort study (total follow-up >12 000 person-years). Setting Leicester, Leicestershire and Rutland (Total Female population of 434 859), UK. Participants Two thousand three hundred and one women with PCOS (mean age = 29·6 years) attending a speciality clinic in Leicestershire, UK. Main outcomes measures T2DM, myocardial infarction (MI), angina, heart failure (HF), stroke and CV-related death. Results Incidence of T2DM, MI, angina, HF, stroke and CV death was respectively 3·6, 0·8, 1·0, 0·3, 0·0 and 0·4 per 1000 person-years. At the end of follow-up, the prevalence of MI in the age groups 45–54, 55–64 and >65 years was 1·9%, 6·0% and 27·3% and of angina was 2·6%, 6·0% and 27·3%, respectively. Age-group-specific odds ratios for the prevalence of MI and angina compared to the local female population ranged between 2·6 (95% CI: 1·0–6·3) and 12·9 (CI: 3·4–48·6) with the highest ratio being for MI in the group >65 years old. Age, history of hypertension and smoking had significant correlations with CV outcomes in the PCOS patients. Conclusion We have shown a high incidence and age-group-specific prevalence of T2DM, MI and angina in the women with PCOS, with over a quarter having had MI or angina in those >65 years. These findings should be considered in the treatment strategies and long-term planning for women with PCOS. |
| Databáze: | OpenAIRE |
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