A very close margin of ≤1 mm predicts a poor outcome in resected buccal cancer patients with a pathological margin of ≤3 mm
| Autor: | Dai Wei Liu, Yu-Chieh Su, Wen Lin Hsu, Shu Mei Chang, Wen-Yen Chiou, Hon Yi Lin, Shih-Kai Hung, Wei Ta Tsai, Feng Chun Hsu, Moon Sing Lee, Szu Chi Li, Tze Ta Huang, Chih En Tseng |
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| Rok vydání: | 2011 |
| Předmět: |
Locoregional control
Medicine(all) medicine.medical_specialty Radiotherapy business.industry medicine.medical_treatment Cancer Chemoradiotherapy General Medicine Buccal administration medicine.disease Surgery Radiation therapy Close margin Margin (machine learning) medicine Carcinoma Radical surgery business Pathological Buccal mucosa carcinoma |
| Zdroj: | Tzu Chi Medical Journal. 23(4):123-130 |
| ISSN: | 1016-3190 |
| DOI: | 10.1016/j.tcmj.2011.10.005 |
| Popis: | Objectives A close margin of ≤3 mm results in a high risk for locoregional recurrence, but still is not an independent factor that helps to guide the use of aggressive postoperative therapies in patients with resected buccal mucosa carcinoma. This suggests there is a diversity of clinical outcomes in this group of patients. The present study explores the predictors among this clinically debated group of patients. Materials and Methods From 2000 to 2008, 30 resected buccal mucosa carcinoma patients with a close margin of ≤3 mm were retrospectively included in this study. All patients were treated with radical surgery together with postoperative radiotherapy (RT) or chemoradiotherapy (CCRT). Locoregional/local/regional control, disease-free status, disease-specific survival and overall survival were the study end points. Results Two factors were observed that were able to predict 5-year locoregional control. These were a pathological N classification (pN0 vs. pN1-2, 71.5% vs. 30.0%, p = 0.044) and a very close margin (> 1 mm vs. ≤1 mm, 81.8% vs. 50.7%, p = 0.040). Remarkably, the predicting effect of a very close margin was well translated into disease-free status (81.8% vs. 47.1%, p = 0.024) and disease-specific survival (100% vs. 70.6%, p = 0.037). After multivariate analysis, a very close margin of ≤1 mm was found to independently predict a high risk of locoregional recurrence (HR, 9.528; 95% CI, 1.326–18.481; p = 0.025) and disease failure at any site (HR, 12.778; 95% CI, 1.934–25.217; p = 0.013). Conclusion More aggressive postoperative treatments should be considered for resected buccal mucosa carcinoma patients with a very close margin of ≤1 mm. |
| Databáze: | OpenAIRE |
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