Increased Glucose Activity in Subgenual Anterior Cingulate and Hippocampus of High Performing Older Adults, Despite Amyloid Burden
| Autor: | Lucas Porcello Schilling, Ana Maria Marques da Silva, Michele Alberton Andrade, Mirna Wetters Portuguez, Cristina M Moriguchi-Jeckel, Eduardo Leal-Conceição, Ricardo Bernardi Soder, Cristina Sebastião Matushita, Paula Kopschina Feltes, Nathalia Bianchini Esper, Louise Mross Hartmann, Alexandre Rosa Franco, Wyllians Vendramini Borelli, Jaderson Costa da Costa, Graciane Radaelli |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Cingulate cortex Oncology medicine.medical_specialty Exceptional memory Amyloid Hippocampus Neuropsychological Tests Hippocampal formation Gyrus Cinguli 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 0501 psychology and cognitive sciences Anterior cingulate cortex Aged Aged 80 and over Amyloid beta-Peptides business.industry General Neuroscience 05 social sciences General Medicine Magnetic Resonance Imaging Cognitive test Psychiatry and Mental health Clinical Psychology Glucose medicine.anatomical_structure Cognitive Aging Positron-Emission Tomography Posterior cingulate Female Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer’s Disease, 81(4), 1419-1428. IOS Press |
| ISSN: | 1875-8908 |
| Popis: | BACKGROUND: Individuals at 80 years of age or above with exceptional memory are considered SuperAgers (SA), an operationalized definition of successful cognitive aging. SA showed increased thickness and altered functional connectivity in the anterior cingulate cortex as a neurobiological signature. However, their metabolic alterations are yet to be uncovered.OBJECTIVE: Herein, a metabolic (FDG-PET), amyloid (PIB-PET), and functional (fMRI) analysis of SA were conducted.METHODS: Ten SA, ten age-matched older adults (C80), and ten cognitively normal middle-aged (C50) adults underwent cognitive testing and multimodal neuroimaging examinations. Anterior and posterior regions of the cingulate cortex and hippocampal areas were primarily examined, then subregions of anterior cingulate were segregated.RESULTS: The SA group showed increased metabolic activity in the left and right subgenual anterior cingulate cortex (sACC, p < 0.005 corrected, bilateral) and bilateral hippocampi (right: p < 0.0005 and left: p < 0.005, both corrected) as compared to that in the C80 group. Amyloid deposition was above threshold in 30% of SA and C80 (p > 0.05). The SA group also presented decreased connectivity between right sACC and posterior cingulate (p < 0.005, corrected) as compared to that of the C80 group.CONCLUSION: These results support the key role of sACC and hippocampus in SA, even in the presence of amyloid deposition. It also suggests that sACC may be used as a potential biomarker in older adults for exceptional memory ability. Further longitudinal studies measuring metabolic biomarkers may help elucidate the interaction between these areas in the cognitive aging process. |
| Databáze: | OpenAIRE |
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