Denosumab-associated osteonecrosis of the jaw--a case report
| Autor: | Sheena Vyas, Vaidyanathan Murugaraj, Sabina Hameed |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Osteoporosis Dentistry Antibodies Monoclonal Humanized Collagen Type I Bone remodeling stomatognathic system Internal medicine medicine Humans Clinical significance Mandibular Diseases Tooth Socket General Dentistry Aged Suppuration business.industry RANK Ligand Follow up studies Osteonecrosis Bisphosphonate medicine.disease stomatognathic diseases Denosumab Monoclonal Tooth Extraction Female business Osteonecrosis of the jaw Peptides Biomarkers medicine.drug Follow-Up Studies |
| Zdroj: | Dental update. 41(5) |
| ISSN: | 0305-5000 |
| Popis: | Osteonecrosis of the jaw (ONJ) following bisphosphonate use is well documented. However, to our knowledge, there are few cases reported on ONJ related to the use of other pharmaceutical agents, such as denosumab – a monoclonal antibody that is prescribed for the treatment of osteoporosis and is used as an anti-cancer agent. Here we present the first case in the UK of a patient who has developed ONJ following treatment with denosumab. The purpose of this report is to highlight the potential effects of this monoclonal antibody on bone turnover and the subsequent results of osteonecrosis of the jaw. It is hoped that this will allow early recognition by medical and dental practitioners, and appropriate referral and treatment. Clinical Relevance: Readers should be aware of other causes of osteonecrosis of the jaw. |
| Databáze: | OpenAIRE |
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