The Study of Rhabdomyolysis in the Elderly: An Epidemiological Study and Single Center Experience
| Autor: | Janani Rangaswami, Supakanya Wongrakpanich, Prithiv Prasad, Andrew Rosenzweig, Christos Kallis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Multivariate analysis fall Renal function Single Center Orginal Article elderly Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology medicine 030212 general & internal medicine biology business.industry Acute kidney injury 030208 emergency & critical care medicine Cell Biology medicine.disease polypharmarcy immobilization Etiology biology.protein rhabdomyolysis Creatine kinase Neurology (clinical) Geriatrics and Gerontology business Rhabdomyolysis |
| Zdroj: | Aging and Disease |
| ISSN: | 2152-5250 |
| Popis: | Rhabdomyolysis is a syndrome caused by injury to skeletal muscle. There is limited data of rhabdomyolysis in the elderly. The objective of this study is to investigate demographic data, etiologies, laboratory values, prognostic factors, and mortality of rhabdomyolysis in the geriatric population. A 4-years retrospective chart review study was conducted. Our inclusion criteria were age above 65 years and creatinine kinase level excess five times of normal upper limit. Among 167 patients, 47.3% were male. The median age at diagnosis was 80.11 (66-101) years. The duration of follow up in the study ranged from 0 to 48 months. Fall (with or without immobilization) was the most frequent cause of rhabdomyolysis in 56.9%. The mean baseline glomerular filtration rate (GFR), GFR at diagnosis, and peak decline in GFR was 76.94, 48.96, and 54.41 cc/min respectively. The mean CK at diagnosis and peak CK was 5097.22 and 6320.07. There were 45 deaths (21%) over the span of 4 years. Multivariate analysis demonstrated that number of medications pre-admission (Meds No.), peak decline in GFR, and acute kidney injury (AKI) are independent predictors for overall survival for rhabdomyolysis in the elderly. To our knowledge, this is the first epidemiological study of rhabdomyolysis in the elderly. Falls (with and without immobilization) were the most common etiology. Meds No. (>8), peak decline in GFR ( |
| Databáze: | OpenAIRE |
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