Microsatellite instability and the association with plasma homocysteine and thymidylate synthase in colorectal cancer
| Autor: | Dorthe G. Crüger, Anders Jakobsen, Ivan Brandslund, Jan Lindebjerg, Lars Henrik Jensen, Steen Kølvraa, Jens Nederby Nielsen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
Cancer Research Homocysteine Colorectal cancer Nutritional Status Adenocarcinoma Biology Reductase Thymidylate synthase Gene Expression Regulation Enzymologic chemistry.chemical_compound Carcinoembryonic antigen medicine Humans Vitamin B12 Promoter Regions Genetic Methylenetetrahydrofolate Reductase (NADPH2) Adaptor Proteins Signal Transducing Aged Aged 80 and over Polymorphism Genetic Nuclear Proteins Microsatellite instability Thymidylate Synthase General Medicine Methylation DNA Methylation Middle Aged medicine.disease Carcinoembryonic Antigen Gene Expression Regulation Neoplastic Oncology chemistry biology.protein Cancer research Female Microsatellite Instability Colorectal Neoplasms MutL Protein Homolog 1 |
| Zdroj: | Jensen, L H, Lindebjerg, J, Crüger, D G, Brandslund, I, Jakobsen, A, Kølvrå, S & Nielsen, J N 2008, ' Microsatellite instability and the association with plasma homocysteine and thymidylate synthase in colorectal cancer ', Cancer Investigation, vol. 26, no. 6, pp. 583-589 . https://doi.org/10.1080/07357900801970992 |
| DOI: | 10.1080/07357900801970992 |
| Popis: | Udgivelsesdato: July The possible associations between microsatellite instability, homocysteine and thymidylate synthase were investigated in tumors and plasma from 130 patients with colorectal cancer. Other analyses included thymidylate synthase and 5,10-methylene-tetrahydrofolate reductase gene polymorphisms, carcinoembryonic antigen, vitamin B12, and folate. Microsatellite instability of tumors was associated with higher levels of plasma homocysteine (p = 0.008) and higher protein expression of thymidylate synthase (p < 0.001). Supplemental analyses ruled out that the finding could be explained by the other analyzed factors. CEA was not associated with neither homocysteine nor microsatellite instability. The data suggests that there is a more pronounced methyl unit deficiency in microsatellite instable tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|