Dyslipidemia and fasting glucose impairment among HIV patients three years after the first antiretroviral regimen in a Brazilian AIDS outpatient clinic
Autor: | Rodrigo Ribeiro-Rodrigues, Kimberly Page, Lauro Ferreira da Silva Pinto Neto, Angélica Espinosa Miranda, Mariza Barros das Neves |
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Rok vydání: | 2012 |
Předmět: |
Microbiology (medical)
Adult Blood Glucose Male medicine.medical_specialty Anti-HIV Agents lcsh:QR1-502 Co-morbidity HIV Infections Ambulatory Care Facilities lcsh:Microbiology lcsh:Infectious and parasitic diseases Cohort Studies Interquartile range Risk Factors Internal medicine medicine Outpatient clinic Humans Cumulative incidence lcsh:RC109-216 Dyslipidemias Retrospective Studies Medicine(all) Fasting glucose Framingham Risk Score business.industry Retrospective cohort study Lopinavir Fasting Middle Aged medicine.disease Surgery AIDS Regimen Infectious Diseases Dyslipidemia Female business ART Brazil medicine.drug |
Zdroj: | Brazilian Journal of Infectious Diseases, Volume: 17, Issue: 4, Pages: 438-443, Published: AUG 2013 Brazilian Journal of Infectious Diseases, Vol 17, Iss 4, Pp 438-443 Brazilian Journal of Infectious Diseases v.17 n.4 2013 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Vol 17, Iss 4, Pp 438-443 (2013) |
ISSN: | 1678-4391 |
Popis: | Objective: To evaluate the cumulative incidence of dyslipidemia and fasting glucose impairment three years after initiating the first antiretroviral (ART) regimen and the association with the type of ART regimen in an AIDS outpatient clinic in Brazil. Methods: Retrospective cohort of HIV-1 infected patients attending an outpatient HIV clinic in Vitoria, Brazil, between January/2010 and May/2011. Data, including blood pressure, dyslipidemia (high total cholesterol and low HDL-C), fasting glucose, and cardiovascular risk by Framingham Risk Score were abstracted from medical records from clinic visits six months prior and three years after starting ART. We assessed independent associated factors for dyslipidemia using multiple logistic regression. Results: Four hundred and ninety-eight patients on ART were studied. Median age was 45 years (interquartile range (IQR): 37–52), and median time since HIV diagnosis was 7.7 years (IQR: 3.8–10.0). The proportion of patients with dyslipidemia was 22.3% (95% CI: 18.6–25.9%) 36 months after ART initiation. Triglycerides levels >150 mg/dL (55.2% vs. 25.4%, p = 0.021) and high fasting glucose (5.8% vs. 2.3%, p = 0.034) were diagnosed more frequently after ART use when compared to baseline values. Multiple logistic regression analysis has shown dyslipidemia to be associated with lopinavir/r use [OR = 1.74 (95% CI: 1.12–2.86)]. Conclusion: These data show high chance of dyslipidemia after initiation of ART. Long-term follow-up will help identify the impact of ART on cardiovascular risk. Keywords: Dyslipidemia, Fasting glucose, AIDS, ART, Co-morbidity |
Databáze: | OpenAIRE |
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