Low adiponectin levels in primary hypertriglyceridemic male patients
| Autor: | María Belén Benítez, Fernando Brites, Luis Cuniberti, Tomás Meroño, Gustavo Giunta, L. Gómez Rosso, R. Wikinski, Graciela López, M.L. D'Ambrosio |
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| Rok vydání: | 2007 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Lipoproteins Population Medicine (miscellaneous) Adipokine Down-Regulation Fatty Acids Nonesterified Body Mass Index Insulin resistance Sex Factors Internal medicine medicine Humans Insulin education Triglycerides Hypertriglyceridemia Metabolic Syndrome education.field_of_study Nutrition and Dietetics Adiponectin business.industry medicine.disease Cholesterol Ester Transfer Proteins Endocrinology Case-Control Studies Metabolic syndrome Insulin Resistance Waist Circumference Cardiology and Cardiovascular Medicine business Lipoprotein |
| Zdroj: | Nutrition, metabolism, and cardiovascular diseases : NMCD. 19(2) |
| ISSN: | 1590-3729 |
| Popis: | Adiponectin is an adipokine highly and specifically expressed by adipose cells with antiatherogenic and antiinflammatory activities. The aim of the present study was to evaluate plasma adiponectin concentration in patients with primary hypertriglyceridemia and its relationship with metabolic parameters.Male patients with primary hypertriglyceridemia and without the metabolic syndrome (n=22) were compared with normotriglyceridemic individuals (n=25). Plasma adiponectin concentration was measured by standardised enzyme-linked immunosorbent assay. Body mass index, waist circumference, glucose, insulin and non-esterified fatty acid levels, lipoprotein profile, and CETP activity were evaluated. Adiponectin levels were significantly decreased in hypertriglyceridemic patients in comparison with normotriglyceridemic subjects (4292+/-1717 vs. 6939+/-3249 ng/ml, p0.005, respectively). Adiponectin was negatively associated with glucose (r=-0.44, p0.01), insulin (r=-0.37, p0.01), HOMA (r=-0.40, p0.01), triglycerides (r=-0.36, p0.01), VLDL-C (r=-0.34, p0.05), and CETP (r=-0.47, p0.001). Positive and significant correlations were observed with QUICKI (r=0.49, p0.001) and HDL-C (r=0.33, p0.05). In the multiple linear regression analysis, considering waist circumference, QUICKI, Log-triglycerides, HDL-C, and CETP as independent variables, Log-adiponectin showed a positive correlation with QUICKI, with an r(2)=0.229 and p0.001. Therefore, the independent variable QUICKI explained the 23% of the variance in Log-adiponectin concentration.We found low adiponectin levels in a population of primary hypertriglyceridemic men without the metabolic syndrome and an independent relationship between adiponectin concentration and insulin resistance. A reduction in insulin sensitivity and its impact on adiponectin concentration could be linked to high non-esterified fatty acid levels, increased triglyceride synthesis in the liver and impaired catabolism of triglyceride-rich lipoproteins. |
| Databáze: | OpenAIRE |
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