Correction of retinal ischemic injuries by using non-selective imidazoline receptor agonists in the experiment
| Autor: | E.A. Levkova, Anna A. Peresypkina, Sergey S. Lugovskoy, Evgeniya Beskhmelnitsyna, Victoria V. Bashuk, Mikhail A. Martynov, Leonid V. Pazhinsky, Anton L. Pazhinsky |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pharmacology Imidazoline receptor agonists Retinal RM1-950 retinal ischemia-reperfusion Wistar rats ATP-dependent potassium channels 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine imidazoline receptor agonists chemistry C7070 030221 ophthalmology & optometry Pharmacology (medical) Therapeutics. Pharmacology |
| Zdroj: | Research Results in Pharmacology, Vol 5, Iss 4, Pp 7-17 (2019) Research Results in Pharmacology 5(4): 7-17 |
| ISSN: | 2658-381X |
| Popis: | Introduction: Retinoprotective effects of non-selective imidazoline receptor agonists: potassium salt of С7070; sodium salt of С7070; С7070 processed with CO2 – were investigated in comparison with C7070 on the retinal ischemia-reperfusion model in rats. Materials and methods: The protective effects of the substances were evaluated by using ophthalmoscopy, laser Doppler flowmetry, electroretinography, histological and morphometric studies of retinal layers. Results and discussion: The most pronounced retinoprotective effect was observed in potassium salt of C7070 at a dose of 10 mg/kg, which expresses in approaching the normal eye fundus image, achieving the target values of the retinal blood flow, b/a coefficient, and reaching the norm values of morphometric indicators. A less pronounced protective effect was found in sodium salt of C7070 at a dose of 10 mg/kg, which expresses in a 71% decrease (p < 0.05) in semi-quantitative assessment of the eye fundus changes, an increase in the retinal blood flow level by 70.4% (p < 0.05), in b/a by 94% (p < 0.05) in comparison with the group without correction, and reaching the norm of the morphometric indicators. A retinoprotective effect of the substance C7070 processed with CO2 at a dose of 10 mg/kg is inferior to that of the sodium salt of C7070. Conclusion: The retinoprotective activity of the substances is expressed in descending order: potassium salt of С7070 (10 mg/kg) ≈ С7070 (50 mg/kg) > sodium salt of С7070 (10 mg/kg) > С7070 processed with CO2 (10 mg/kg) ≈ С7070 (10 mg/kg). Injections of glibenclamide leveled the neuroretinoprotective effects of the substances to varying degrees, which confirmed the participation of ATP-dependent potassium channels in the implementation of these effects. |
| Databáze: | OpenAIRE |
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