A Case of Postoperative Recurrence of Fibrolamellar Hepatocellular Carcinoma with Increased Vitamin B12 Binding Capacity in a Young Japanese Female
| Autor: | Yukio Kawano, Naoto Miyazawa, Shigeru Kuramochi, Tsukasa Takabayashi, Toshio Kanai |
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| Rok vydání: | 2004 |
| Předmět: |
Cancer Research
medicine.medical_specialty Surgical margin Carcinoma Hepatocellular Adolescent medicine.medical_treatment Inferior vena cava medicine Hepatectomy Humans Radiology Nuclear Medicine and imaging Postoperative Period Vitamin B12 Transcobalamins Chemotherapy business.industry Liver Neoplasms General Medicine medicine.disease Chemotherapy regimen Surgery Oncology Fibrolamellar hepatocellular carcinoma medicine.vein Lymphatic Metastasis Hepatocellular carcinoma Neoplasm Recurrence Local Tomography X-Ray Computed business Epirubicin medicine.drug |
| Zdroj: | Japanese Journal of Clinical Oncology. 34:346-351 |
| ISSN: | 1465-3621 0368-2811 |
| DOI: | 10.1093/jjco/hyh050 |
| Popis: | A 17-year-old Japanese female underwent major hepatic resection for a huge fibrolamellar hepatocellular carcinoma that was compressing the inferior vena cava. The tumor was not exposed at the surgical margin but was very close to it. A recurrent lesion at the surgical margin of the liver and a lymph node metastasis were discovered 9 months postoperatively together with a marked elevation of vitamin B 1 2 binding capacity. These lesions were resected, and vitamin B 1 2 binding capacity decreased thereafter. Peritoneal dissemination was detected by CT 16 months postoperatively, together with recurrent elevation of vitamin B 1 2 binding capacity. Several types of chemotherapy, including intraperitoneal injection of epirubicin, were applied and improved the patient's quality of life somewhat, but the patient died of recurrent disease 34 months after the initial hepatic resection. This is the first report in Japan of fibrolamellar hepatocellular carcinoma with increased vitamin B 1 2 binding capacity as a useful marker. Fibrolamellar hepatocellular carcinomas, if resected, have a better prognosis than ordinary hepatocellular carcinoma in Japan, as well as in Western countries. An aggressive strategy should be chosen, which consists mainly of precise surgical resection and postoperative multi-modality therapy, including chemotherapy. |
| Databáze: | OpenAIRE |
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