TGF-β and microvessel homeostasis
| Autor: | Tony E. Walshe |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pathology
medicine.medical_specialty Growth factor medicine.medical_treatment GDF2 Cell Biology Endoglin Biology Biochemistry medicine.anatomical_structure Transforming Growth Factor beta Transforming growth factor beta 3 Microvessels Cancer research medicine Animals Homeostasis Humans Pericyte Cardiology and Cardiovascular Medicine Receptor Microvessel Transforming growth factor |
| Zdroj: | Microvascular Research. 80:166-173 |
| ISSN: | 0026-2862 |
| DOI: | 10.1016/j.mvr.2010.03.003 |
| Popis: | Aberrant transforming growth factor-beta (TGF-beta) signaling plays a clear role in a number of pathologies, in particular, fibrotic diseases and cancer. Accumulating evidence also suggests that TGF-beta is required for vascular homeostasis, shedding light on the role of circulating TGF-beta and the expression of TGF-beta receptors in the adult vasculature, in the absence of any pathologic processes. In human pathologies such as hereditary hemorrhagic telangiectasia (HHT) and preeclampsia, TGF-beta signaling is abnormal. Studies from these disorders have helped elucidate the complex and multiple roles of this ubiquitously-expressed growth factor. The aim of this review is to collate some of the recent evidence that demonstrates a non-redundant role for TGF-beta signaling in maintaining vessel structure and function. |
| Databáze: | OpenAIRE |
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