Signalling through the JAK–STAT pathway in the developing brain
| Autor: | Claudio De-Fraja, Elena Cattaneo, Luciano Conti |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Transcriptional Activation
Aging Embryo Nonmammalian Activator (genetics) General Neuroscience medicine.medical_treatment Brain JAK-STAT signaling pathway Protein-Tyrosine Kinases Biology Embryo Mammalian stat Hedgehog signaling pathway Cell biology Embryonic and Fetal Development Cytokine Animals Newborn STAT protein medicine Animals Signal transduction Janus kinase Neuroscience Signal Transduction |
| Zdroj: | Trends in Neurosciences. 22:365-369 |
| ISSN: | 0166-2236 |
| Popis: | The JAK -STAT (Janus kinase-signal transducer and activator of transcription) signalling pathway that is stimulated by cytokines has been much investigated in haematopoietic cells, but recent data indicate that this pathway is also present and active during neuronal and glial differentiation. Furthermore, it is now clear that growth factors other than the classical cytokines can act through this pathway and that physiological inhibitors of this signalling cascade exist. Thus, the JAKs, the STATs and their specific inhibitors could be molecules with important roles in the CNS. |
| Databáze: | OpenAIRE |
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