Serum neurofilament light chain (NFL) remains unchanged during electroconvulsive therapy
| Autor: | Michael Belz, David Zilles, Jens Wiltfang, Petra Steinacker, Jonathan Vogelgsang, Matthias Besse, Isabel Methfessel, Markus Otto, Thorsten Folsche |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_treatment
Neurofilament light Intermediate Filaments Brain damage Bioinformatics behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine Electroconvulsive therapy Neurofilament Proteins mental disorders medicine Humans ddc:610 Electroconvulsive Therapy Biological Psychiatry Depressive Disorder Major therapy [Depressive Disorder Major] business.industry 3. Good health 030227 psychiatry Psychiatry and Mental health medicine.symptom business metabolism [Neurofilament Proteins] 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | The world journal of biological psychiatry 21(2), 148-154 (2020). doi:10.1080/15622975.2019.1702717 |
| ISSN: | 1814-1412 |
| DOI: | 10.1080/15622975.2019.1702717 |
| Popis: | Objectives: Although there is consistent evidence that electroconvulsive therapy (ECT) is safe and well tolerated by the majority of patients, some authors still accuse ECT to inevitably cause brain damage and permanent memory loss, assertions that may increase patients’ worries about a useful treatment. Recently, the measurement of neurofilament light chain (NFL) in peripheral blood was technically implemented, permitting longitudinal analysis of this biomarker for axonal damage. NFL is part of the axonal cytoskeleton and is released into the CSF and peripheral blood in the context of neuronal damage.Methods: In our study, blood from 15 patients with major depressive disorder receiving ECT was collected before the first ECT as well as 24 h and seven days after the last ECT, respectively. NFL concentrations were analysed using the ultrasensitive single molecule array (Simoa) technology.Results: NFL concentrations did not differ between patients and healthy controls, and there was no significant change in NFL levels in the course of ECT. On the contrary, we even found a slight decrease in absolute NFL concentrations.Conclusions: Our study confirms the safety of ECT by using a most sensitive method for the detection of NFL in peripheral blood as a biomarker of neuronal damage. |
| Databáze: | OpenAIRE |
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