Re-testing of predictive biomarkers on surgical breast cancer specimens is clinically relevant
Autor: | Stephanie Robertson, Johan Hartman, Jana de Boniface, Caroline Rönnlund |
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Rok vydání: | 2019 |
Předmět: |
Adult
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Receptor ErbB-2 Concordance Estrogen receptor Breast Neoplasms 03 medical and health sciences 0302 clinical medicine Breast cancer Drug Therapy Internal medicine Progesterone receptor Biomarkers Tumor medicine Humans Mastectomy Aged Retrospective Studies Aged 80 and over business.industry Retrospective cohort study Middle Aged medicine.disease Neoadjuvant Therapy Ki-67 Antigen 030104 developmental biology Receptors Estrogen 030220 oncology & carcinogenesis Cohort Biomarker (medicine) Immunohistochemistry Female Biopsy Large-Core Needle Receptors Progesterone business |
Zdroj: | Breast Cancer Research and Treatment. 174:795-805 |
ISSN: | 1573-7217 0167-6806 |
Popis: | The accuracy of predictive and prognostic biomarker assessment in breast cancer is paramount since these guide therapy decisions. The aim was to investigate the concordance of biomarkers and immunohistochemical (IHC)-based surrogate tumor subtypes between core needle biopsies (CNB) and consecutive paired breast cancer surgical resections. This retrospective study comprised two cohorts of patients with primary breast cancer diagnosed between 2016 and 2017: one treated with primary surgery (n = 526) and one with neoadjuvant chemotherapy (NAC) (n = 216). The agreement between preoperative CNB and paired tumor specimens regarding the assessment of biomarkers and surrogate tumor subtypes was evaluated in both cohorts. In the primary surgery cohort, the concordance rates and kappa values for estrogen receptor (ER), progesterone receptor (PR) and Ki67 were 98.6% (κ = 0.917), 89.3% (κ = 0.725) and 78.8% (κ = 0.529), respectively. Importantly, human epidermal growth factor receptor 2 (HER2) IHC assessment showed only moderate agreement (κ = 0.462). HER2 status combining IHC and in situ hybridization was discordant in 3.6% of cases, potentially impacting on indications for HER2-targeted therapy. The concordance rate for IHC-based surrogate tumor subtypes was only 73.2–78.3%. Generally lower concordance rates for ER, PR and HER2 were observed in the NAC cohort. Here, HER2 status was discordant in 7.4%. The agreement of HER2 and Ki67 between CNB and paired surgical specimen in primary breast cancer is insufficient. Limited agreement of surrogate tumor subtypes indicates a significant clinical value of biomarker re-testing on surgical specimens. |
Databáze: | OpenAIRE |
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