Six Month Follow-up of Patients With Multi-System Inflammatory Syndrome in Children
| Autor: | Suchitra S. Acharya, Elizabeth Mitchell, Andrew D. Blaufox, Denise A. Hayes, Sujatha Rajan, Nilanjana Misra, Mary Beth Kearney, Richard A. Friedman, Madhusudan Ganigara, Angela Romano, Christine Capone, Charles Schleien, Rubin Cooper, Shilpi Epstein |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Diastole Standard score Ventricular Function Left Immunomodulating Agents Ventricular Dysfunction Left Intensive care Vasoactive Internal medicine Medicine Humans Longitudinal Studies Outpatient Monitoring Child Uncertain significance business.industry Coronary Aneurysm COVID-19 Infant Heart Coronary Vessels Magnetic Resonance Imaging Systemic Inflammatory Response Syndrome COVID-19 Drug Treatment Myocarditis Child Preschool Pediatrics Perinatology and Child Health Cardiology Female business Cohort study Month follow up |
| Zdroj: | Pediatrics. 148(4) |
| ISSN: | 1098-4275 |
| Popis: | BACKGROUND AND OBJECTIVES Myocardial dysfunction and coronary abnormalities are prominent features of multisystem inflammatory syndrome in children (MIS-C). In this study we aim to evaluate the early and midterm outcomes of MIS-C. METHODS This is a longitudinal 6-month cohort study of all children admitted and treated for MIS-C from April 17 to June 20, 2020. Patients were followed ∼2 weeks, 8 weeks, and 6 months postadmission, with those with coronary aneurysms evaluated more frequently. RESULTS Acutely, 31 (62%) patients required intensive care with vasoactive support, 26 (52%) had left ventricular (LV) systolic dysfunction, 16 (32%) had LV diastolic dysfunction, 8 (16%) had coronary aneurysms (z score ≥2.5), and 4 (8%) had coronary dilation (z score CONCLUSIONS Children with MIS-C treated with immunomodulators have favorable early outcomes with no mortality, normalization of LV systolic function, recovery of coronary abnormalities, and no inflammation or scarring on cardiac MRI. Persistence of diastolic dysfunction is of uncertain significance and indicates need for larger studies to improve understanding of MIS-C. These findings may help guide clinical management, outpatient monitoring, and considerations for sports clearance. |
| Databáze: | OpenAIRE |
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