Evaluation of distribution, redox parameters, and genotoxicity in Wistar rats co-exposed to silver and titanium dioxide nanoparticles
| Autor: | Fernando Barbosa, Cecília Cristina de Souza Rocha, Rodrigo de Carvalho Hott, Maria Fernanda Hornos Carneiro, Lara Ferreira Azevedo, Abayomi Tolulope Ogunjimi, Lusânia Maria Greggi Antunes, Joseph A. Adeyemi, Vinicius Paula Venancio, Jairo Lisboa Rodrigues, Mara Ribeiro Almeida, Airton Cunha Martins |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Silver Health Toxicology and Mutagenesis Metal Nanoparticles 010501 environmental sciences Toxicology medicine.disease_cause 01 natural sciences Redox Silver nanoparticle 03 medical and health sciences chemistry.chemical_compound Sodium citrate medicine Animals Tissue Distribution Rats Wistar 0105 earth and related environmental sciences chemistry.chemical_classification Titanium biology Glutathione peroxidase Glutathione Rats Comet assay 030104 developmental biology chemistry Biochemistry Catalase biology.protein Environmental Pollutants Oxidation-Reduction Genotoxicity Blood Chemical Analysis Nuclear chemistry DNA Damage |
| Zdroj: | Journal of toxicology and environmental health. Part A. 80(19-21) |
| ISSN: | 1528-7394 |
| Popis: | The increasing production of silver nanoparticles (AgNPs) and titanium dioxide nanoparticles (TiO2NPs) has resulted in their elevated concentrations in the environment. This study was, therefore, aimed at determining the distribution, redox parameters, and genotoxic effects in male Wistar rats that were treated with either AgNP or TiO2NP individually, as well as under a co-exposure scenario. Animals were exposed via oral gavage to either sodium citrate buffer (vehicle), 0.5 mg/kg/day TiO2NP, 0.5 mg/kg/day AgNP or a mixture of TiO2NPs and AgNPs. Exposure lasted 45 days after which rats were sacrificed, and tissue biodistribution of Ag and Ti measured. The blood concentration of glutathione (GSH) and activities of glutathione peroxidase (GPx) and catalase (CAT) were determined while the genotoxicity was analyzed using the comet assay in peripheral blood and liver cells. The tissue concentrations of Ag followed the order; blood > liver > kidneys while for Ti the order was kidneys > liver > blood. The... |
| Databáze: | OpenAIRE |
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