Laparoscopic total gastrectomy for multiple sporadic gastric gastrointestinal stromal tumors: report of a case
| Autor: | You Ichinose, Shigeki Uchida, Hiroshi Okabe, Toshihiro Kobayashi, Tetsu Sasaoki, Kenzo Goto, Akihisa Fujimoto |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Laparoscopic surgery medicine.medical_specialty Pathology Gastrointestinal Stromal Tumors medicine.medical_treatment PDGFRA Gastroenterology Neoplasms Multiple Primary Germline mutation Gastrectomy Stomach Neoplasms Surgical oncology Internal medicine Humans Medicine Family history Antrum business.industry Stomach digestive oral and skin physiology General Medicine Middle Aged Curvatures of the stomach digestive system diseases medicine.anatomical_structure Laparoscopy Surgery business |
| Zdroj: | Surgery Today. 42:84-88 |
| ISSN: | 1436-2813 0941-1291 |
| Popis: | A 64-year-old man was admitted to our hospital with hematemesis. Emergency upper gastrointestinal endoscopy revealed bleeding from a submucosal tumor (SMT) in the antrum of the stomach, with two other SMTs at different sites. Based on his family history, we diagnosed familial multiple gastric gastrointestinal stromal tumors (GISTs) and performed laparoscopic total gastrectomy. Three distinct tumors were found: one in the fornix, one in the lesser curvature of the angle, and one in the antrum of the stomach. Microscopic examination of the resected specimens revealed different cytomorphologies, of the spindle and epithelioid type, as well as immunophenotypes in the tumors. Mutation analysis revealed different sites of mutation in c-kit and PDGFRA. No mutation was detected in the normal tissue of the stomach. These findings confirmed a diagnosis of multiple sporadic gastric GISTs. Thus, investigating germline mutation might assist in the preoperative diagnosis of multiple gastric GISTs. |
| Databáze: | OpenAIRE |
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