Clinical relevance of brain atrophy assessment in multiple sclerosis. Implications for its use in a clinical routine
| Autor: | Ralph R H Benedict, Niels Bergsland, Michael Barnett, Rahil Ahmed, Michael G. Dwyer, Robert Zivadinov, Dana Horakova, Manuela Vaneckova, Sirin Gandhi, Bianca Weinstock-Guttman, Dejan Jakimovski |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Multiple Sclerosis 030218 nuclear medicine & medical imaging White matter 03 medical and health sciences 0302 clinical medicine Atrophy medicine Humans Pharmacology (medical) Clinical significance Intensive care medicine Brain Diseases medicine.diagnostic_test General Neuroscience Multiple sclerosis Confounding Brain Cognition Magnetic resonance imaging Clinical routine medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Neurology (clinical) Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Expert Review of Neurotherapeutics. 16:777-793 |
| ISSN: | 1744-8360 1473-7175 |
| Popis: | Introduction: Brain atrophy measurement in multiple sclerosis (MS) has become an important outcome for determining patients at risk for developing physical and cognitive disability.Areas covered: In this article, we discuss the methodological issues related to using this MRI metric routinely, in a clinical setting. Understanding trajectories of annualized whole brain, gray and white matter, thalamic volume loss, and enlargement of ventricular space in specific MS phenotypes is becoming increasingly important. Evidence is mounting that disease-modifying treatments exert a positive effect on slowing brain atrophy progression in MS.Expert Commentary: While there is a need to translate measurement of brain atrophy to clinical routine at the individual patient level, there are still a number of challenges to be met before this can actually happen, including how to account for biological confounding factors and pseudoatrophy, standardize acquisition and analyses parameters, which can influence the accur... |
| Databáze: | OpenAIRE |
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