Differentiation of Saccadic Eye Movement Signals
| Autor: | Roberto Becerra-García, Gonzalo Joya, Rodolfo García-Bermúdez |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Visual perception
Computer science TP1-1185 Biochemistry Article Analytical Chemistry saccades identification 03 medical and health sciences Saccades medicine Humans numerical differentiation Electrical and Electronic Engineering Latency (engineering) Instrumentation saccades biomarkers computing 030304 developmental biology electrooculograms 0303 health sciences business.industry Angular displacement Chemical technology Pattern recognition medicine.disease Atomic and Molecular Physics and Optics Saccadic masking Electrooculography Noise Parametric model Saccade Spinocerebellar ataxia Artificial intelligence business |
| Zdroj: | Sensors (Basel, Switzerland) Sensors, Vol 21, Iss 5021, p 5021 (2021) Sensors Volume 21 Issue 15 |
| ISSN: | 1424-8220 |
| DOI: | 10.3390/s21155021 |
| Popis: | Saccadic electrooculograms are discrete biosignals that contain the instantaneous angular position of the human eyes as a response to saccadic visual stimuli. These signals are essential to monitor and evaluate several neurological diseases, such as Spinocerebellar Ataxia type 2 (SCA2). For this, biomarkers such as peak velocity, latency and duration are computed. To compute these biomarkers, we need to obtain the velocity profile of the signals using numerical differentiation methods. These methods are affected by the noise present in the electrooculograms, specially in subjects that suffer neurological diseases. This noise complicates the comparison of the differentiation methods using real saccadic signals because of the impossibility of establishing exact saccadic onset and offset points. In this work, we evaluate 16 differentiation methods by the design of an experiment that uses synthetic saccadic electrooculograms generated from parametric models of both healthy subjects and subjects suffering from Spinocerebellar Ataxia type 2 (SCA2). For these synthetic electrooculograms the exact velocity profile is known, hence we can use them as a reference for comparison and error computing for the tasks of saccade identification and saccade biomarker computing. Finally, we identify the best fitting method or methods for each evaluated task. |
| Databáze: | OpenAIRE |
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