The Presence of (1→3)-β-D-Glucan as Prognostic Marker in Patients After Major Abdominal Surgery
| Autor: | Jessica S Price, Christian Parr, Rosemary Ann Barnes, Malcolm A. Finkelman, P. Lewis White, Raquel Posso |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty beta-Glucans 030106 microbiology Sensitivity and Specificity Gastroenterology Proinflammatory cytokine Persistence (computer science) Serology 03 medical and health sciences Immune system Internal medicine medicine Humans Candidiasis Invasive Glucans business.industry Mortality rate Micafungin Prognosis Clinical trial 030104 developmental biology Infectious Diseases business medicine.drug Abdominal surgery |
| Zdroj: | Clinical Infectious Diseases. 73:e1415-e1422 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | Background While the serological detection of (1→3)-β-D-glucan (BDG) can indicate invasive fungal disease (IFD), false positivity occurs. Nevertheless, the presence of BDG can still be recognized by the host’s innate immune system and persistent BDG antigenemia, in the absence of IFD, can result in deleterious proinflammatory immune responses. Methods During the XXX (INTENSE) study into the preemptive use of micafungin to prevent invasive candidiasis (IC) after abdominal surgery, the serum burden of BDG was determined to aid diagnosis of IC. Data from the INTENSE study were analyzed to determine whether BDG was associated with organ failure and patient mortality, while accounting for the influences of IC and antifungal therapy. Results A BDG concentration >100 pg/mL was associated with a significantly increased Sequential Organ Failure Assessment score (≤100 pg/mL: 2 vs >100 pg/mL: 5; P < .0001) and increased rates of mortality (≤100 pg/mL: 13.7% vs >100 pg/mL: 39.0%; P = .0002). Multiple (≥2) positive results >100 pg/mL or a BDG concentration increasing >100 pg/mL increased mortality (48.1%). The mortality rate in patients with IC and a BDG concentration >100 pg/mL and ≤100 pg/mL was 42.3% and 25.0%, respectively. The mortality rate in patients without IC but a BDG concentration >100 pg/mL was 37.3%. The use of micafungin did not affect the findings. Conclusions The presence of persistent or increasing BDG in the patient’s circulation is associated with significant morbidity and mortality after abdominal surgery, irrespective of IC. The potential lack of a specific therapeutic focus has consequences when trying to manage these patients, and when designing clinical trials involving patients where host-associated BDG concentrations may be elevated. Clinical Trials Registration NCT01122368. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|