Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis
| Autor: | Xiaojian Yin, Xingxing Cao, Zhou Liu, Shouchao Wei, Li Hu, Guoda Ma, Haihong Zhou, Xiaoping Peng, Chunmei Jiang, Huiliang Li, Yingren Mai, Bin Zhao, Kanglan Li, Zhongkai Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Multiple Sclerosis Article Subject Immunology Blotting Western Fluorescent Antibody Technique Gut flora 03 medical and health sciences Therapeutic approach Myelin Feces Mice 0302 clinical medicine Microscopy Electron Transmission RNA Ribosomal 16S medicine Pathology RB1-214 Animals Myelin Sheath biology Microglia business.industry Multiple sclerosis Experimental autoimmune encephalomyelitis Therapeutic effect Cell Biology Fecal Microbiota Transplantation medicine.disease biology.organism_classification Axons Gastrointestinal Microbiome Mice Inbred C57BL Disease Models Animal 030104 developmental biology medicine.anatomical_structure Blood-Brain Barrier Female business Dysbiosis 030217 neurology & neurosurgery Research Article |
| Zdroj: | Mediators of Inflammation Mediators of Inflammation, Vol 2020 (2020) |
| ISSN: | 0962-9351 |
| DOI: | 10.1155/2020/2058272 |
| Popis: | Given the growing evidence of a link between gut microbiota (GM) dysbiosis and multiple sclerosis (MS), fecal microbiota transplantation (FMT), aimed at rebuilding GM, has been proposed as a new therapeutic approach to MS treatment. To evaluate the viability of FMT for MS treatment and its impact on MS pathology, we tested FMT in mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. We provide evidence that FMT can rectify altered GM to some extent with a therapeutic effect on EAE. We also found that FMT led to reduced activation of microglia and astrocytes and conferred protection on the blood-brain barrier (BBB), myelin, and axons in EAE. Taken together, our data suggest that FMT, as a GM-based therapy, has the potential to be an effective treatment for MS. |
| Databáze: | OpenAIRE |
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