Overview of genomics and post-genomics research on type 2 diabetes mellitus: Future perspectives and a framework for further studies
| Autor: | Battini Mohan Reddy, Rayabarapu Pranavchand, S.A.A. Latheef |
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| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Future studies Genomic data Genomic research Type 2 Diabetes Mellitus Computational Biology India Genomics General Medicine Disease 01 natural sciences Data science Post genomics General Biochemistry Genetics and Molecular Biology Diabetes Mellitus Type 2 Research strategies Humans Metabolomics Gene-Environment Interaction General Agricultural and Biological Sciences Psychology 010606 plant biology & botany |
| Zdroj: | Journal of biosciences. 44(1) |
| ISSN: | 0973-7138 |
| Popis: | In this review, we briefly outlined salient features of pathophysiology and results of the genetic association studies hitherto conducted on type 2 diabetes. Primarily focusing on the current status of genomic research, we briefly discussed the limited progress made during the post-genomic era and tried to identify the limitations of the post-genomic research strategies. We suggested reanalysis of the existing genomic data through advanced statistical and computational methods and recommended integrated genomics-metabolomics approaches for future studies to facilitate understanding of the gene-environment interactions in the manifestation of the disease. We also propose a framework for research that may be apt for determining the effects of urbanization and changing lifestyles in the manifestation of complex genetic disorders like type 2 diabetes in the Indian populations and offset the confounding effects of both genetic and environmental factors in the natural way. |
| Databáze: | OpenAIRE |
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