Analysis of Hematological Traits in Polled Yak by Genome-Wide Association Studies Using Individual SNPs and Haplotypes
| Autor: | Ping Yan, Chunnian Liang, Xiaoming Ma, Xian Guo, Donghai Fu, Congjun Jia, Xuezhi Ding, Bao Pengjia, Min Chu, Wu Xiaoyun, Jie Pei |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Candidate gene lcsh:QH426-470 hematological traits Population Single-nucleotide polymorphism Genome-wide association study Biology Polymorphism Single Nucleotide Genome Article 03 medical and health sciences Genetics Animals Genetic variability education Genetics (clinical) Genetic association education.field_of_study single-marker GWAS Altitude Haplotype 0402 animal and dairy science 04 agricultural and veterinary sciences 040201 dairy & animal science lcsh:Genetics Phenotype 030104 developmental biology Haplotypes Animals Domestic haplotype analysis Cattle polled yak Genome-Wide Association Study |
| Zdroj: | Genes Volume 10 Issue 6 Genes, Vol 10, Iss 6, p 463 (2019) |
| ISSN: | 2073-4425 |
| Popis: | Yak (Bos grunniens) is an important domestic animal living in high-altitude plateaus. Due to inadequate disease prevention, each year, the yak industry suffers significant economic losses. The identification of causal genes that affect blood- and immunity-related cells could provide preliminary reference guidelines for the prevention of diseases in the population of yaks. The genome-wide association studies (GWASs) utilizing a single-marker or haplotype method were employed to analyze 15 hematological traits in the genome of 315 unrelated yaks. Single-marker GWASs identified a total of 43 significant SNPs, including 35 suggestive and eight genome-wide significant SNPs, associated with nine traits. Haplotype analysis detected nine significant haplotype blocks, including two genome-wide and seven suggestive blocks, associated with seven traits. The study provides data on the genetic variability of hematological traits in the yak. Five essential genes (GPLD1, EDNRA, APOB, HIST1H1E, and HIST1H2BI) were identified, which affect the HCT, HGB, RBC, PDW, PLT, and RDWSD traits and can serve as candidate genes for regulating hematological traits. The results provide a valuable reference to be used in the analysis of blood properties and immune diseases in the yak. |
| Databáze: | OpenAIRE |
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