Temperature and non-aromatizable androgens: a common pathway in male sex determination in a turtle with temperature-dependent sex determination?
| Autor: | Judith M. Bergeron, David Crews, Amador R. Cantu |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Sex Determination Analysis medicine.medical_specialty Female sex determination medicine.drug_class Endocrinology Diabetes and Metabolism Male sex determination Biology Androsterone chemistry.chemical_compound Endocrinology Internal medicine medicine Animals Sex Ratio Incubation Dose-Response Relationship Drug Temperature-dependent sex determination Hatching Temperature Dihydrotestosterone Androgen Androstane-3 17-diol Turtles chemistry Female medicine.drug |
| Zdroj: | Journal of Endocrinology. 149:457-463 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1677/joe.0.1490457 |
| Popis: | This study addressed the hypothesis that, in the red-eared slider turtle, Trachemys scripta, non-aromatizable androgens are the physiological equivalent of temperature in determining male development. In the first experiment, eggs were treated in the middle of the temperature-sensitive period with 1·0 or 10·0 μg androsterone, 5α-dihydrotestosterone, 3α-androstanediol, or 3β-androstanediol, while at an all-male, male-biased, or one of two female-biased incubation temperatures. In the second experiment, eggs were treated with the same dosages of dihydrotestosterone at different stages of embryonic development while at a male-biased, threshold, or a female-biased incubation temperature. Results of experiment one indicated that hormone-induced masculinization is specific to non-aromatizable androgens. Results of experiment two indicated that the sensitivity to dihydrotestosterone corresponds to the temperature-sensitive window during development. Further, there is a dose–response relationship but no apparent synergism between exogenous dihydrotestosterone and incubation temperature. When considered with other research, it is suggested that non-aromatizable androgens and their products are involved in the initiation of male sex determination whereas oestrogens and their aromatizable androgen precursors are involved in the initiation of female sex determination. Journal of Endocrinology (1996) 149, 457–463 |
| Databáze: | OpenAIRE |
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