A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine
Autor: | Guo, Yanjun, Rist, Pamela M., Daghlas, Iyas, Giulianini, Franco, Gormley, Padhraig, Anttila, Verneri, Winsvold, Bendik S., Palta, Priit, Esko, Tonu, Pers, Tune H., Farh, Kai How, Cuenca-Leon, Ester, Muona, Mikko, Furlotte, Nicholas A., Kurth, Tobias, Ingason, Andres, McMahon, George, Ligthart, Lannie, Terwindt, Gisela M., Kallela, Mikko, Freilinger, Tobias M., Ran, Caroline, Gordon, Scott G., Stam, Anine H., Steinberg, Stacy, Borck, Guntram, Koiranen, Markku, Quaye, Lydia, Adams, Hieab H.H., Lehtimäki, Terho, Sarin, Antti Pekka, Wedenoja, Juho, Hinds, David A., Buring, Julie E., Schürks, Markus, Ridker, Paul M., Hrafnsdottir, Maria Gudlaug, Stefansson, Hreinn, Ring, Susan M., Hottenga, Jouke Jan, Penninx, Brenda W.J.H., Färkkilä, Markus, Artto, Ville, Kaunisto, Mari, Vepsäläinen, Salli, Malik, Rainer, Heath, Andrew C., Madden, Pamela A.F., Martin, Nicholas G., Montgomery, Grant W., Kurki, Mitja, Kals, Mart, Mägi, Reedik, Pärn, Kalle, Hämäläinen, Eija, Huang, Hailiang, Byrnes, Andrea E., Franke, Lude, Huang, Jie, Stergiakouli, Evie, Lee, Phil H., Sandor, Cynthia, Webber, Caleb, Cader, Zameel, Muller-Myhsok, Bertram, Schreiber, Stefan, Meitinger, Thomas, Eriksson, Johan G., Salomaa, Veikko, Heikkilä, Kauko, Loehrer, Elizabeth, Uitterlinden, Andre G., Hofman, Albert, Duijn, Cornelia M.van, Cherkas, Lynn, Pedersen, Linda M., Stubhaug, Audun, Nielsen, Christopher S., Männikkö, Minna, Mihailov, Evelin, Milani, Lili, Göbel, Hartmut, Esserlind, Ann Louise, Christensen, Anne Francke, Hansen, Thomas Folkmann, Werge, Thomas, Kaprio, Jaakko, Aromaa, Arpo J., Raitakari, Olli, Ikram, M. Arfan, Spector, Tim, Järvelin, Marjo Riitta, Metspalu, Andres, Kubisch, Christian, Strachan, David P., Ferrari, Michel D., Belin, Andrea C., Dichgans, Martin, Wessman, Maija, Maagdenberg, Arn M.J.M.van den, Zwart, John Anker, Boomsma, Dorret I., Smith, George Davey, Stefansson, Kari, Eriksson, Nicholas, Daly, Mark J., Neale, Benjamin M., Olesen, Jes, Chasman, Daniel I., Nyholt, Dale R., Palotie, Aarno, Agee, Michelle, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Huber, Karen E., Kleinman, Aaron, Litterman, Nadia K., McCreight, Jennifer C., McIntyre, Matthew H., Mountain, Joanna L., Noblin, Elizabeth S., Northover, Carrie A.M., Pitts, Steven J., Sathirapongsasuti, J. Fah, Sazonova, Olga V., Shelton, Janie F., Shringarpure, Suyash, Tian, Chao, Tung, Joyce Y., Vacic, Vladimir |
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Přispěvatelé: | Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, Psychiatry, APH - Digital Health, Radiology & Nuclear Medicine, Epidemiology, Neurology, Internal Medicine, Biological Psychology, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, APH - Methodology, Clinicum, Neurologian yksikkö, HUS Neurocenter, HUS Helsinki and Uusimaa Hospital District, Department of Neurosciences, Research Programs Unit, Institute for Molecular Medicine Finland, Neuroscience Center, STEMM - Stem Cells and Metabolism Research Program, Genomics of Neurological and Neuropsychiatric Disorders, Department of Public Health, Biosciences, Centre of Excellence in Complex Disease Genetics, Research Programme of Molecular Medicine, Aarno Palotie / Principal Investigator, Helsinki University Hospital Area, University of Helsinki, Johan Eriksson / Principal Investigator, Department of General Practice and Primary Health Care |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Netherlands Twin Register (NTR) Integrin beta Chains LOCI Medizin General Physics and Astronomy Blood Pressure Genome-wide association study Genome-wide association studies DISEASE 3124 Neurology and psychiatry 0302 clinical medicine HEADACHE Risk Factors Polymorphism (computer science) Genome-wide lcsh:Science Telomerase Multidisciplinary Mendelian Randomization Analysis Blóðþrýstingur 3. Good health Pulse pressure Mígreni Hypertension Blood pressure Cross-phenotype Erfðarannsóknir medicine.medical_specialty Migraine Disorders Science Diastole Polymorphism Single Nucleotide Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Meta-Analysis as Topic SDG 3 - Good Health and Well-being Receptors Adrenergic alpha-2 Internal medicine Mendelian randomization medicine Humans Genetic Predisposition to Disease Migraine business.industry Proteins General Chemistry medicine.disease Meta-analysis 030104 developmental biology Endocrinology RISK-FACTORS lcsh:Q business 030217 neurology & neurosurgery Genome-Wide Association Study |
Zdroj: | Nat. Commun. 11:3368 (2020) Nature Communications, 11(1):3368. Nature Publishing Group UK Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020) Guo, Y, Rist, P M, Daghlas, I, Giulianini, F, Gormley, P, Anttila, V, Winsvold, B S, Palta, P, Esko, T, Pers, T H, Farh, K H, Cuenca-Leon, E, Muona, M, Furlotte, N A, Kurth, T, Ingason, A, McMahon, G, Ligthart, L, Terwindt, G M, Kallela, M, Freilinger, T M, Ran, C, Gordon, S G, Stam, A H, Steinberg, S, Borck, G, Koiranen, M, Quaye, L, Adams, H H H, Lehtimäki, T, Sarin, A P, Wedenoja, J, Hinds, D A, Buring, J E, Schürks, M, Ridker, P M, Hrafnsdottir, M G, Stefansson, H, Ring, S M, Hottenga, J J, Penninx, B W J H, Färkkilä, M, Artto, V, Kaunisto, M, Vepsäläinen, S, Malik, R, Christensen, A F, Hansen, T F, Werge, T, Olesen, J, The International Headache Genetics Consortium & the 23andMe Research Team 2020, ' A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine ', Nature Communications, vol. 11, no. 1, 3368 . https://doi.org/10.1038/s41467-020-17002-0 Guo, Y, Rist, P M, Daghlas, I, Giulianini, F, Gormley, P, Anttila, V, Winsvold, B S, Palta, P, Esko, T, Pers, T H, Farh, K H, Cuenca-Leon, E, Muona, M, Furlotte, N A, Kurth, T, Ingason, A, McMahon, G, Ligthart, L, Terwindt, G M, Kallela, M, Freilinger, T M, Ran, C, Gordon, S G, Stam, A H, Steinberg, S, Borck, G, Koiranen, M, Quaye, L, Adams, H H H, Lehtimäki, T, Sarin, A P, Wedenoja, J, Hinds, D A, Buring, J E, Schürks, M, Ridker, P M, Hrafnsdottir, M G, Stefansson, H, Ring, S M, Hottenga, J J, Penninx, B W J H, Färkkilä, M, Artto, V, Kaunisto, M, Vepsäläinen, S, Malik, R, Heath, A C, Madden, P A F, Martin, N G, Montgomery, G W, Kurki, M, Kals, M, Mägi, R, Pärn, K, Hämäläinen, E, Huang, H, Byrnes, A E, Franke, L, Huang, J, Stergiakouli, E, Lee, P H, Sandor, C, Webber, C, Cader, Z, Muller-Myhsok, B, Schreiber, S, Meitinger, T, Eriksson, J G, Salomaa, V, Heikkilä, K, Loehrer, E, Uitterlinden, A G, Hofman, A, Duijn, C M V, Cherkas, L, Pedersen, L M, Stubhaug, A, Nielsen, C S, Männikkö, M, Mihailov, E, Milani, L, Göbel, H, Esserlind, A L, Christensen, A F, Hansen, T F, Werge, T, Kaprio, J, Aromaa, A J, Raitakari, O, Ikram, M A, Spector, T, Järvelin, M R, Metspalu, A, Kubisch, C, Strachan, D P, Ferrari, M D, Belin, A C, Dichgans, M, Wessman, M, Maagdenberg, A M J M V D, Zwart, J A, Boomsma, D I, Smith, G D, Stefansson, K, Eriksson, N, Daly, M J, Neale, B M, Olesen, J, Chasman, D I, Nyholt, D R, Palotie, A, Agee, M, Auton, A, Bell, R K, Bryc, K, Elson, S L, Fontanillas, P, Furlotte, N A, Hinds, D A, Huber, K E, Kleinman, A, Litterman, N K, McCreight, J C, McIntyre, M H, Mountain, J L, Noblin, E S, Northover, C A M, Pitts, S J, Sathirapongsasuti, J F, Sazonova, O V, Shelton, J F, Shringarpure, S, Tian, C, Tung, J Y, Vacic, V, Kurth, T, Chasman, D I, The International Headache Genetics Consortium & the 23andMe Research Team 2020, ' A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine ', Nature Communications, vol. 11, no. 1, 3368 . https://doi.org/10.1038/s41467-020-17002-0 Nature Communications, 11(1):3368, 1-11. Nature Publishing Group Nature communications Guo, Y, Ligthart, L, Hottenga, J J, Penninx, B W J H, Boomsma, D I, Chasman, D I, The International Headache Genetics Consortium & The 23andMe Research Team 2020, ' A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine ', Nature Communications, vol. 11, no. 1, 3368, pp. 1-11 . https://doi.org/10.1038/s41467-020-17002-0 Nature Communications |
ISSN: | 2041-1723 |
Popis: | Publisher's version (útgefin grein) Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, rg = 0.11, P = 3.56 × 10−06) and systolic BP (SBP, rg = 0.06, P = 0.01), but not pulse pressure (PP, rg = −0.01, P = 0.75). Cross-trait meta-analysis reveals 14 shared loci (P ≤ 5 × 10−08), nine of which replicate (P This research has been conducted using the UK Biobank Resource under Application Number 29273. We would like to thank the participants and researchers from the UK Biobank, 23andMe, Inc., International Headache Genetics Consortium (IHGC), MEGASTROKE, CARDIoGRAM, and International Consortium of Blood Pressure-Genome Wide Association Studies (ICBP) who contributed or collected data. Daniel I. Chasman is funded by US National Institutes of Health and US National Institute of Neurological Disorders and Stroke (R21NS09296 and R21NS104398). Pamela M. Rist is funded by K01 HL128791. The MEGASTROKE project received funding from sources specified at http://www.megastroke.org/acknowledgments.html. |
Databáze: | OpenAIRE |
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