Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats
| Autor: | Anil Kumar, Neha Seghal, Pattipati S. Naidu, S.S.V. Padi |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Curcumin Medicine (miscellaneous) Pharmacology medicine.disease_cause Cerebral Ventricles chemistry.chemical_compound Memory Medicine Colchicine Animals Rats Wistar Cognitive impairment Maze Learning Nitrites Brain Chemistry Nutrition and Dietetics Behavior Animal business.industry Brain Glutathione Rats Oxidative Stress chemistry Anesthesia Acetylcholinesterase Lipid Peroxidation business Cognition Disorders Oxidative stress |
| Zdroj: | Journal of medicinal food. 10(3) |
| ISSN: | 1096-620X |
| Popis: | This study was designed to investigate the protective effects of curcumin against colchicine-induced cognitive impairment and oxidative stress in rats. Male Wistar rats (weighing 150-200 g) received colchicine intracerebroventricularly (15 microg per rat), and cognitive dysfunctions were evaluated by the Morris water maze and the plus maze performance task and supported by biochemical tests. Central administration of colchicine caused memory deficit in both the Morris water maze and the elevated plus maze task paradigm tasks. Chronic treatment with curcumin (5-50 mg/kg, p.o.) twice daily for a period of 25 days beginning 4 days prior to colchicine injection significantly improved the colchicine-induced cognitive impairment. Biochemically, chronic administration of curcumin significantly reduced the elevated lipid peroxidation, restored the decreased reduced glutathione level and acetylcholinesterase activity, and attenuated the raised colchicine-induced elevated nitrite levels. The results of the present study indicate that curcumin has a protective role against colchicine-induced cognitive impairment and associated oxidative stress. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|