Recent Progress in the Construction of Functional Artificial Bone by Cytokine-Controlled Strategies
| Autor: | Guo-Hua Xu, Meng-Chao Shi, Xiao-Gang Bao, Chun-Lin Hou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
PubMed Artificial bone Bone Regeneration Angiogenesis medicine.medical_treatment Functional Artificial Bone lcsh:Medicine Review Article 02 engineering and technology Bioinformatics 03 medical and health sciences Key point Spatio-Temporal Analysis Osteogenesis medicine Animals Humans Bone regeneration Retrospective Studies Tissue Engineering business.industry Ossification Regeneration (biology) lcsh:R General Medicine 021001 nanoscience & nanotechnology Cytokines Spatiotemporal Delivery 030104 developmental biology Cytokine medicine.anatomical_structure Bone marrow medicine.symptom 0210 nano-technology business |
| Zdroj: | Chinese Medical Journal, Vol 131, Iss 21, Pp 2599-2604 (2018) Chinese Medical Journal |
| ISSN: | 0366-6999 |
| Popis: | Objective: Combining artificial scaffolds with stimulatory factors to reconstruct lost bone tissues is one of the hottest research directions. The purpose of this review was to conduct a retrospective survey on the latest reports on artificial bone fabrication with functional cytokines. Data Sources: The status of related scientific research from the year 2005 to 2018 was analyzed through the mode of literature retrieval in PubMed and VIP Database. The retrieval words are as follows: "bone tissue engineering," "angiogenesis," "cytokines," "osteogenesis," "biomimetic bone marrow," "sol-gel," "delivery system," and the corresponding Chinese words. Study Selection: After reading through the title and abstract for early screening, the full text of relevant studies was evaluated and those not related with this review had been ruled out. Results: According to the literature retrospective survey, there were three key points for the successful construction of functional artificial bones: (1) the continuous supply of relatively low concentration of cytokines during the required period; (2) the delivery of two or more cytokines essential to the process and ensure the relatively spatial independence to reduce the unnecessary interference; and (3) supporting the early-stage angiogenesis and late-stage osteogenesis, respectively, regulating and balancing the crosslinking of both to avoid the surface ossification that would probably block the osteogenesis inside. Conclusions: The synergistic effect of both angiogenic factors and osteogenic factors applied in bone regeneration is a key point in the combined functional artificial bone. Through analysis, comparison, and summary of the current strategies, we proposed that the most promising one is to mimic the natural bone marrow function to facilitate the regeneration process and ensure the efficient repair of large weight-bearing bone defect. Key words: Angiogenesis; Cytokines; Functional Artificial Bone; Osteogenesis; Spatiotemporal Delivery |
| Databáze: | OpenAIRE |
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