The Paradox of Coenzyme Q10 in Aging
| Autor: | José L. Quiles, Pilar González-García, Maurizio Battino, Luis C. López, M Elena Díaz-Casado, Eliana Barriocanal-Casado, Alfonso Varela-López |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Aging antioxidant Mitochondrial Diseases Antioxidant Ubiquinone aging-related diseases medicine.medical_treatment mitohormesis Mitochondrion medicine.disease_cause Antioxidants Mice chemistry.chemical_compound 0302 clinical medicine Inner mitochondrial membrane Muscle Weakness Nutrition and Dietetics food and beverages Middle Aged Aging-related diseases Cell biology Mitochondria mitochondria Female lcsh:Nutrition. Foods and food supply Adult lcsh:TX341-641 Young Adult 03 medical and health sciences Hormesis Mitohormesis Biosynthesis medicine Animals Humans Caenorhabditis elegans Coenzyme Q10 anti-aging Diet Rats Metabolic pathway 030104 developmental biology chemistry Coenzyme Q – cytochrome c reductase Ataxia diet 030217 neurology & neurosurgery Oxidative stress Food Science |
| Zdroj: | Digibug. Repositorio Institucional de la Universidad de Granada instname Nutrients, Vol 11, Iss 9, p 2221 (2019) |
| Popis: | Coenzyme Q (CoQ) is an essential endogenously synthesized molecule that links different metabolic pathways to mitochondrial energy production thanks to its location in the mitochondrial inner membrane and its redox capacity, which also provide it with the capability to work as an antioxidant. Although defects in CoQ biosynthesis in human and mouse models cause CoQ deficiency syndrome, some animals models with particular defects in the CoQ biosynthetic pathway have shown an increase in life span, a fact that has been attributed to the concept of mitohormesis. Paradoxically, CoQ levels decline in some tissues in human and rodents during aging and coenzyme Q10 (CoQ10) supplementation has shown benefits as an anti-aging agent, especially under certain conditions associated with increased oxidative stress. Also, CoQ10 has shown therapeutic benefits in aging-related disorders, particularly in cardiovascular and metabolic diseases. Thus, we discuss the paradox of health benefits due to a defect in the CoQ biosynthetic pathway or exogenous supplementation of CoQ10. This work was supported by grants from Ministerio de Ciencia, Innovación y Universidades, Spain, and the ERDF (Grant Number RTI2018-093503-B-I00), from the Muscular Dystrophy Association (grant number 602322) and from the University of Granada (grant reference “UNETE”, UCE-PP2017-06). E.B.-C. is supported by the Junta de Andalucía. P.G.-G. is a “FPU fellow” from the Ministerio de Educación Cultura y Deporte, Spain |
| Databáze: | OpenAIRE |
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