Interaction of smoking and radon in rats: A biologically based mechanistic model
| Autor: | W. F. Heidenreich, J. P. Morlier, G. Monchaux |
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| Přispěvatelé: | Forschungszentrum fur Umwelt und Gesundheit (GSF), Helmholtz Zentrum München = German Research Center for Environmental Health, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Laboratoire de Cancérologie Expérimentale (LCE), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Helmholtz-Zentrum München (HZM) |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Neoplasms
Radiation-Induced Lung Neoplasms Time Factors Target cells [SDV]Life Sciences [q-bio] animal experiment Biophysics chemistry.chemical_element Radon radiation exposure Pharmacology Models Biological Biophysical Phenomena smoking 030218 nuclear medicine & medical imaging Toxicology Dose-Response Relationship 03 medical and health sciences 0302 clinical medicine Radon dose Models Dosimetry Neoplasms Cigarette smoke Animals Humans Animalia rat cell interaction target cell General Environmental Science nonhuman Cocarcinogenesis Radiation Targets cigarette smoke animal model article Dose-Response Relationship Radiation radon Biological Clonal expansion models respiratory tract diseases Rats chemistry Radiation-Induced 030220 oncology & carcinogenesis Cloning |
| Zdroj: | Radiation and Environmental Biophysics Radiation and Environmental Biophysics, 2005, 44 (2), pp.145-148. ⟨10.1007/s00411-005-0006-3⟩ |
| Popis: | Data on rats exposed to cigarette smoke before or after exposure to radon are used to estimate smoke-dependent parameters of the biologically based two-stage clonal expansion model. The baseline parameters and the action of radon acting on initiation and promotion were fixed based on earlier work. Cigarette smoke acting on transformation and inducing a reduction of the radon dose to the target cells after a smoking period gives an acceptable description of the data. © Springer-Verlag 2005. |
| Databáze: | OpenAIRE |
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