Pre-pectoral breast reconstruction: early and long-term safety evaluation of 146 unselected cases of the early pre-pectoral era of a single-institution, including cases with previous breast irradiation and post-mastectomy radiation therapy
| Autor: | V. Salvestrini, Isacco Desideri, Victoria Lorenzetti, Carlotta Becherini, L. Visani, Jacopo Nori, G. Stocchi, Silvia Sordi, Simonetta Bianchi, Marco Bernini, C. Bellini, Lorenzo Orzalesi, Diego De Benedetto, Icro Meattini, Calogero Saieva, Lorenzo Livi |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Implant based breast reconstruction Post-mastectomy radiation therapy Pre-pectoral breast reconstruction Breast surgery medicine.medical_treatment Breast Implants Mammaplasty Breast Neoplasms Breast cancer Postoperative Complications Surgical oncology medicine Humans Pharmacology (medical) Radiology Nuclear Medicine and imaging Mastectomy Retrospective Studies business.industry BRCA mutation Tissue Expansion Devices General Medicine medicine.disease Comorbidity Surgery Radiation therapy Oncology Female Radiotherapy Adjuvant Neoplasm Recurrence Local Breast reconstruction business Body mass index |
| Zdroj: | Breast cancer (Tokyo, Japan). 29(2) |
| ISSN: | 1880-4233 |
| Popis: | We re-evaluated acute and early-late toxicity-related factors among pre-pectoral immediate tissue expander/implant (TE/I) breast reconstruction (BR) unselected, first-era, cases, including previous breast radiation treatment and post-mastectomy radiation therapy (PMRT). A retrospective analysis of 146 (117 therapeutic and 29 prophylactic) pre-pectoral reconstructions, between 2012 and 2016, considered patient-related (age, body mass index [BMI], smoke-history, comorbidity, BRCA mutation), and treatment-related characteristics (previous irradiation, axillary surgery, PMRT, pre- and postoperative chemotherapy, endocrine therapy, and target-therapy). Safety was evaluated as acute and early-late complications, and TE/I failures. At multivariate analysis of the 146 cases (117 patients submitted to BR) a significant factor related to acute toxicity was: BMI ≥ 25 (31.3% [≥ 25] vs 8.8% [ |
| Databáze: | OpenAIRE |
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