Fluorene/Fluorenone Carboxamide Derivatives As Selective Light-Up Fluorophores For C-Myc G-Quadruplex
| Autor: | Osman Doluca, Zeynel Seferoğlu, Ergin Yalçın, Halil Duyar, Beyza Kanat, Huseyin Saygin Portakal |
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| Přispěvatelé: | Mühendislik ve Doğa Bilimleri Fakültesi -- Mühendislik Temel Bilimleri Bölümü, Yalçın, Ergin |
| Rok vydání: | 2021 |
| Předmět: |
Fluorenone
medicine.drug_class Clinical Biochemistry Pharmaceutical Science Carboxamide Fluorene G-quadruplex Medicinal 01 natural sciences Biochemistry Proto-Oncogene Mas Proto-Oncogene Proteins c-myc chemistry.chemical_compound Structure-Activity Relationship c-myc G-Quadruplex Drug Discovery medicine Humans heterocyclic compounds Light-up probe Molecular Biology Fluorescent Dyes Fluorenes Organic Dose-Response Relationship Drug Molecular Structure 010405 organic chemistry Organic Chemistry DNA Combinatorial chemistry Fluorescence 0104 chemical sciences G-Quadruplexes Chemistry 010404 medicinal & biomolecular chemistry chemistry G-Structure Thrombin Aptamer Molecular Medicine Light Up Selectivity |
| Popis: | © 2021 Elsevier LtdThe development of fluorescent dyes capable of selective recognition of G-quadruplexes is essential for studying its localization and biological functions. However, considering the G-quadruplex topologies may vary significantly, the synthesis of compounds showing both selectivity and strong fluorescence properties still remains a great challenge. Recently we have developed fluorene/fluorenone derivatives with structure-specific binding towards dsRNA, indicating its potential for structure-selective ligands. Herein, we report the synthesis of novel fluorene/fluorenone derivatives and their selectivity towards various DNA structures, particularly G-quadruplexes, two of which showed strong affinity to the proto-oncogene c-myc promoter G-quadruplex. |
| Databáze: | OpenAIRE |
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