Renoprotective effect of tolvaptan in patients with new‐onset acute heart failure
| Autor: | Tetsuro Sugiura, Kei Yoshioka, Ichiro Shiojima, Mitsuru Yokoi, Hiroki Takahashi, Kenichi Fujii, Haengnam Park, Yoshihiro Yamamoto, Hiromi Kin, Koichiro Matsumura, Munemitsu Otagaki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty Tolvaptan Worsening renal function Renal function 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Furosemide Internal medicine Original Research Articles medicine Humans 030212 general & internal medicine Original Research Article Diuretics Retrospective Studies Heart Failure Creatinine Ejection fraction business.industry Acute heart failure Odds ratio medicine.disease Confidence interval chemistry lcsh:RC666-701 Heart failure Cardiology Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | ESC Heart Failure ESC Heart Failure, Vol 7, Iss 4, Pp 1764-1770 (2020) |
| ISSN: | 2055-5822 |
| Popis: | Aims Although tolvaptan has been reported to prevent worsening renal function (WRF) in patients with advanced acute heart failure (AHF), evidence regarding the effect of tolvaptan on renal function in patients with new‐onset AHF is not available. This study aimed to investigate the renoprotective effect of tolvaptan in patients hospitalized with new‐onset AHF. Methods and results A total of 122 consecutive patients hospitalized with new‐onset AHF between May 2015 and December 2018 were retrospectively evaluated. WRF was defined as an absolute increase in serum creatinine ≥0.3 mg/dL (≥26.4 μmol/L) within 48 h or a 1.5‐fold increase in serum creatinine after hospitalization. The furosemide group (n = 75) and the tolvaptan add‐on group (n = 47) were compared. The tolvaptan group consists of patients who received tolvaptan as an individual physicians' decision. The incidence of WRF was significantly lower in the tolvaptan add‐on group (8.5%) than in the furosemide group (24.0%, P = 0.03). Multivariate logistic regression analysis revealed that tolvaptan treatment was an independent variable related to the prevention of WRF [odds ratio (OR), 0.20; 95% confidence interval (CI), 0.05–0.85]. Furthermore, subgroup analysis revealed a more favourable effect of tolvaptan in patients with serum creatinine ≥1.1 mg/dL on admission (OR, 0.23; 95% CI, 0.06–0.98) and an ejection fraction |
| Databáze: | OpenAIRE |
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