Features of primary extranodal lymphoma in Kanagawa, a human T-cell leukemia virus type 1 nonendemic area in Japan
Autor: | Atsuko Fujita, Shigeki Motomura, Naoto Tomita, Michiko Hattori, Koji Ogawa, Yoshiaki Ishigatsubo, Fumio Kodama, Heiwa Kanamori, Hiroyuki Fujita, Kenji Motohashi, Etsuko Yamazaki, Shin Fujisawa, Rie Hyo |
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Rok vydání: | 2008 |
Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology Adolescent Lymphoma Tonsillar Neoplasms Follicular lymphoma Japan Internal medicine Prevalence medicine Humans Aged Gastrointestinal Neoplasms Neoplasm Staging Aged 80 and over Human T-lymphotropic virus 1 Hematology biology business.industry Age Factors General Medicine Middle Aged medicine.disease biology.organism_classification Marginal zone HTLV-I Infections Survival Rate Leukemia Lymphatic system Oncology Female Lymphoma Large B-Cell Diffuse business Diffuse large B-cell lymphoma |
Zdroj: | Medical Oncology. 26:49-54 |
ISSN: | 1559-131X 1357-0560 |
Popis: | We sought to determine the frequency of primary extranodal lymphoma (ENL) and its characteristics in Kanagawa, a human T-cell leukemia virus type 1 (HTLV-1) nonendemic area in Japan. Subjects were 847 newly diagnosed patients with malignant lymphoma at the Yokohama City University Hospital and 8 affiliated hospitals mainly located in Kanagawa prefecture from 1999 to 2005. We compared the clinicopathological characteristics of primary ENL with primary nodal lymphoma (NL). Histological specimens were evaluated according to the World Health Organization classifications. A total of 395 (46.6%) and 452 (53.4%) patients had primary ENL and primary NL, respectively. The frequency of primary ENL increased with age. Primary extranodal sites included the gastrointestinal tract (30.4%), Waldeyer's ring (17.8%), orbits (7.0%), soft tissue and subcutaneous tissue (5.2%), bone (4.6%), skin (4.3%), thyroid gland (4.3%), testis and prostate (3.3%), bone marrow (3.3%), nasal and paranasal cavities (2.6%), salivary glands (2.3%), lung and pleura (2.0%), breast (1.8%), central nervous system (1.0%), uterus and ovary (0.5%), and others (9.8%). Among the 395 cases of primary ENL, diffuse large B-cell lymphoma (61.2%) was most frequently diagnosed, followed by extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (13.3%) and follicular lymphoma (5.6%). The frequency of primary ENL is approximately 50% of the total lymphoma cases in Kanagawa, an HTLV-1 nonendemic area in Japan. This frequency appears to be higher than that in Western countries. |
Databáze: | OpenAIRE |
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