Comparison between admission natriuretic peptides, NGAL and sST2 testing for the prediction of worsening renal function in patients with acutely decompensated heart failure

Autor:	Benedetta De Berardinis, Hanna K. Gaggin, Laura Magrini, Arianna Belcher, Benedetta Zancla, Alexandra Femia, Mandy Simon, Shweta Motiwala, Anju Bhardwaj, Blair A. Parry, John T. Nagurney, Charles Coudriou, Matthieu Legrand, Malha Sadoune, Salvatore Di Somma, James L. Januzzi, null from the Global Research on Acute C
Rok vydání:	2015
Předmět:	Male medicine.medical_specialty Acute decompensated heart failure medicine.drug_class Clinical Biochemistry Renal function Receptors Cell Surface Cardiorenal syndrome Kidney B-type natriuretic peptides (BNP) cardiorenal syndrome neutrophil gelatinase associated lipocalin (NGAL) worsening renal function Patient Admission Lipocalin-2 Proto-Oncogene Proteins Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans Aged Heart Failure cardiorenal syndrome business.industry Biochemistry (medical) neutrophil gelatinase associated lipocalin (NGAL) General Medicine Emergency department Prognosis medicine.disease Interleukin-1 Receptor-Like 1 Protein Lipocalins Peptide Fragments B-type natriuretic peptides (BNP) Endocrinology ROC Curve Solubility Area Under Curve Heart failure Acute Disease worsening renal function Cohort Disease Progression Cardiology Biomarker (medicine) Female Emergency Service Hospital business Biomarkers Blood Chemical Analysis Acute-Phase Proteins
Zdroj:	Clinical Chemistry and Laboratory Medicine (CCLM). 53
ISSN:	1437-4331 1434-6621
DOI:	10.1515/cclm-2014-0191
Popis:	BACKGROUND In order to predict the occurrence of worsening renal function (WRF) and of WRF plus in-hospital death, 101 emergency department (ED) patients with acute decompensated heart failure (ADHF) were evaluated with testing for amino-terminal pro-B-type natriuretic peptide (NT-proBNP), BNP, sST2, and neutrophil gelatinase associated lipocalin (NGAL). METHODS In a prospective international study, biomarkers were collected at the time of admission; the occurrence of subsequent in hospital WRF was evaluated. RESULTS In total 26% of patients developed WRF. Compared to patients without WRF, those with WRF had a longer in-hospital length of stay (LOS) (mean LOS 13.1±13.4 days vs. 4.8±3.7 days, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64af1d49d402010ea4bf2751a8b8aa6b https://doi.org/10.1515/cclm-2014-0191 Zobrazit plný text záznamu