Estrogen, natriuretic peptides and the renin–angiotensin system
| Autor: | Kuroski de Bold Ml |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Physiology medicine.drug_class Peptide hormone Renin-Angiotensin System Atrial natriuretic peptide Physiology (medical) Internal medicine Natriuretic Peptide Brain Renin–angiotensin system medicine Animals Homeostasis Humans Endocrine system Testosterone Cardioprotective Agent business.industry Myocardium Estrogens Middle Aged Brain natriuretic peptide Rats Endocrinology Receptors Estrogen Cardiovascular Diseases Estrogen Hypertension Female Cardiology and Cardiovascular Medicine business Atrial Natriuretic Factor Hormone |
| Zdroj: | Cardiovascular Research. 41:524-531 |
| ISSN: | 0008-6363 |
| DOI: | 10.1016/s0008-6363(98)00324-1 |
| Popis: | There are significant gender-specific differences in the incidence of hypertension and the clinical outcome of cardiovascular disease between premenopausal women and age-matched men, suggesting that sex hormones such as estrogen (E) might be responsible for the observed cardioprotective effects. This cardioprotective action of E is thought to involve lipoproteins. However, the effect of E on the lipid profile accounts for about 50% of the reduction in cardiovascular disease, indicating that there might be other mechanisms by which E exerts its cardioprotective effects. At present, the underlying mechanism of E action is poorly understood. In this review, the interplay between E, the natriuretic peptides (NP) and the renin-angiotensin system (RAS) is examined. It is hypothesized that E might, through endocrine and/or paracrine action, modulate cardiac NP in females by affecting the RAS either directly or indirectly. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|