Structure-activity relationship of coordinated catecholamine in the [Ru(III)(NH3)4(catecholamine)]+ complex
| Autor: | Márcio A.F. de Godoy, Mario Sérgio Pereira Marchesi, Roberto Santana da Silva, Renata Galvão de Lima, Ana Maria de Oliveira, Adriano Oliano Cassano |
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| Rok vydání: | 2004 |
| Předmět: |
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Intrinsic activity Stereochemistry Pharmaceutical Science chemistry.chemical_element Protonation In Vitro Techniques Medicinal chemistry Redox Structure-Activity Relationship Catecholamines medicine Organometallic Compounds Animals Rats Wistar Muscle Skeletal Aqueous solution Chemistry Ligand Quinone Ruthenium Rats Catecholamine Ruthenium Compounds Oxidation-Reduction medicine.drug Muscle Contraction |
| Zdroj: | International journal of pharmaceutics. 271(1-2) |
| ISSN: | 0378-5173 |
| Popis: | The redox chemistry and pharmacological studies of the novel blue ruthenium(III)–catecholamine complexes were investigated in aqueous medium and compared to the free catecholamines. The [Ru III (NH 3 ) 4 (catecholamine)] + can be oxidized or reduced reversibly in one electron redox couples in aqueous solution. This is in contrast to the free catecholamines, which has a complicated electrochemical behavior due to coupled protonation process. The introduction of the ruthenium group reduces the intrinsic efficacy of the studied catecholamines. The [Ru III (NH 3 ) 4 (catecholamine)] + complex aqueous medium is more stable than the free catecholamines ligand in the same conditions. |
| Databáze: | OpenAIRE |
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