Potential of tailored amorphous multiporous calcium silicate glass for pulp capping regenerative endodontics—A preliminary assessment
| Autor: | Matthias M. Falk, Himanshu Jain, Hassan M.M. Moawad, Tia J. Kowal, Xiaofei Zhu, Jie Liu, George T.-J. Huang, Brian R Morrow, Ukrit Thamma, Chao-An Chen |
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| Rok vydání: | 2021 |
| Předmět: |
Molar
Regenerative Endodontics Materials science Regenerative endodontics Biocompatibility Swine Dental Pulp Capping Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine stomatognathic system Dental pulp stem cells Animals 030212 general & internal medicine General Dentistry Dental Pulp Silicates 030206 dentistry Calcium Compounds Amorphous solid Pulp capping stomatognathic diseases chemistry Calcium silicate Pulp (tooth) Biomedical engineering |
| Zdroj: | J Dent |
| ISSN: | 0300-5712 |
| Popis: | Introduction/Objective The tailored amorphous multi-porous (TAMP) material fabrication technology has led to a new class of bioactive materials possessing versatile characteristics. It has not been tested for dental applications. Thus, we aimed to assess its biocompatibility and ability to regenerate dental mineral tissue. Methods 30CaO-70SiO2 model TAMP discs were fabricated by a sol-gel method followed by in vitro biocompatibility testing with isolated human or mini-swine dental pulp stem cells (DPSCs). TAMP scaffolds were tested in vivo as a pulp exposure (pin-point, 1 mm, 2 mm, and entire pulp chamber roof) capping material in the molar teeth of mini-swine. Results The in vitro assays showed that DPSCs attached well onto the TAMP discs with comparable viability to those attached to culture plates. Pulp capping tests on mini-swine showed that after 4.5 months TAMP material was still present at the capping site, and mineral tissue (dentin bridge) had formed in all sizes of pulp exposure underneath the TAMP material. Conclusions TAMP calcium silicate is biocompatible with both human and swine DPSCs in vitro and with pulp in vivo, it may help regenerate the dentin bridge after pulp exposure. |
| Databáze: | OpenAIRE |
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