Polymorphisms of the GSTT1 and GSTM1 genes in women of central Serbia: Absence of association with uterine myoma
| Autor: | Ivana Stošić, Olivera Milošević-Djordjević, Darko Grujičić, Dragoslav Marinkovic, Slobodan Arsenijevic, Biljana Ljujic |
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| Rok vydání: | 2013 |
| Předmět: |
central Serbia
Physiology General Biochemistry Genetics and Molecular Biology polymorphism 03 medical and health sciences 0302 clinical medicine Healthy control Genotype Medicine Significant risk Uterine myoma lcsh:QH301-705.5 neoplasms Gene GSTT1 030219 obstetrics & reproductive medicine integumentary system business.industry Gst polymorphism 3. Good health lcsh:Biology (General) 030220 oncology & carcinogenesis General Agricultural and Biological Sciences business GSTM1 |
| Zdroj: | Archives of Biological Sciences, Vol 65, Iss 2, Pp 415-420 (2013) |
| ISSN: | 1821-4339 0354-4664 |
| Popis: | Since glutathione S-transferase (GST) enzymes are involved in cellular protection, we aimed to determine the distribution of GSTT1 and GSTM1 null genotypes in women in central Serbia in order to assess the risk of development of uterine myoma. The study consisted of 34 clinically diagnosed uterine myoma patients and 35 healthy control women. Analyses of GST polymorphism were carried out by multiplex PCR. Our results showed no significant differences in the GSTT1 and GSTM1 null genotypes between the patients and controls. Using the GSTT1 positive/GSTM1 positive combination as reference, there was no statistically significant risk of uterine myoma with the combination of GSTT1 null and GSTM1 null genotypes. We conclude that polymorphism of both GSTT1 and GSTM1 genes, alone or in combination, did not present the main risk for uterine myoma in women from central Serbia.[Projekat Ministarstva nauke Republike Srbije, br. III41010 i br. ON 175103] |
| Databáze: | OpenAIRE |
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